Severity of hepatopulmonary syndrome

A-a gradient	PaO₂ (on room air)	Graded severity
≥15 mmHg (≥2 kPa)	≥80 mmHg (≥10.7 kPa)	Mild
≥15 mmHg (≥2 kPa)	≥60 mmHg and <80 mmHg (≥8 kPa and <10.7 kPa)	Moderate
≥15 mmHg (≥2 kPa)	≥50 mmHg and <60 mmHg (≥6.7 kPa and <8 kPa)	Severe
≥15 mmHg (≥2 kPa)	<50 mmHg (<6.7 kPa)*	Very severe

A-a gradient: Alveolar-arterial oxygen gradient; PaO₂: arterial oxygen tension.
* Patients with a PaO₂ <300 mmHg (40 kPa) while breathing 100% oxygen also have very severe hepatopulmonary syndrome.

Reproduced with permission of the European Respiratory Society ©: European Respiratory Journal Nov 2004; 24(5): 861-880. DOI: 10.1183/09031936.04.00010904.

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