WHO grading myelofibrosis

Grade	Definition
MF-0	Scattered linear reticulin with no intersections (crossovers) corresponding to normal bone marrow
MF-1	Loose network of reticulin with many intersections, especially in perivascular areas
MF-2	Diffuse and dense increase in reticulin with extensive intersections, occasionally with focal bundles of thick fibers mostly consistent with collagen, and/or focal osteosclerosis*
MF-3	Diffuse and dense increase in reticulin with extensive intersections and coarse bundles of thick fibers consistent with collagen, usually associated with osteosclerosis*

Semiquantitative grading of bone marrow fibrosis with minor modifications concerning collagen and osteosclerosis. Fiber density should be assessed only in hematopoietic areas.

MF: myelofibrosis.
* In grades MF-2 or MF-3 an additional trichrome stain is recommended.

Republished with permission of the American Society of Hematology, from Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 2016; 127:2391. Copyright © 2016; permission conveyed through Copyright Clearance Center, Inc.

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WHO grading myelofibrosis