Induction chemotherapy | |||||
Regimen | Drug | Dose | Timing | ||
A | Vincristine | 2 mg/m2 (maximum 2 mg) IV over 1 minute, day 1 | Weeks 1, 5, and 9 | ||
Doxorubicin | 37.5 mg/m2 IV over 1 to 15 minutes, days 1 and 2 | ||||
Cyclophosphamide | 1200 mg/m2 IV over 30 to 60 minutes, day 1, with mesna | ||||
Filgrastim | 5 mcg/kg per day (maximum 300 mcg) starting day 3* | ||||
B | Ifosfamide | 1800 mg/m2 IV over 1 hour, days 1 to 5, with mesna | Weeks 3, 7, and 11 | ||
Etoposide | 100 mg/m2 IV over 1 to 2 hours, days 1 to 5 | ||||
Filgrastim | 5 mcg/kg per day (maximum 300 mcg) starting day 6* | ||||
Consolidation chemotherapy¶ | |||||
Regimen | Drug | Dose | Surgery alone | RT alone | Surgery and RT |
A | Vincristine | 2 mg/m2 (maximum 2 mg) IV over 1 minute, day 1 | Weeks 15 and 19 | Weeks 13 (with the start of RT) and 25 | Weeks 15 (with the start of RT) and 27 |
Doxorubicin | 37.5 mg/m2 IV over 1 to 15 minutes, days 1 and 2 | ||||
Cyclophosphamide | 1200 mg/m2 IV over 30 to 60 minutes, day 1, with mesna | ||||
Filgrastim | 5 mcg/kg per day (maximum 300 mcg) starting day 3* | ||||
B | Ifosfamide | 1800 mg/m2 IV over 1 hour, days 1 to 5, with mesna | Weeks 17, 21, 25, and 29 | Weeks 15, 19, 23, and 27 | Weeks 17, 21, 25, and 29 |
Etoposide | 100 mg/m2 IV over 1 to 2 hours, days 1 to 5 | ||||
Filgrastim | 5 mcg/kg per day (maximum 300 mcg) starting day 6* | ||||
C | Vincristine | 2 mg/m2 (maximum 2 mg) IV over 1 minute, day 1 | Weeks 23 and 27 | Weeks 17 and 21 | Weeks 19 and 23 |
Cyclophosphamide | 1200 mg/m2 IV over 30 to 60 minutes, day 1, with mesna | ||||
Filgrastim | 5 mcg/kg per day (maximum 300 mcg) starting day 3* |
آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟