Mean and CI of plasma concentrations of propofol required to obtain each of the different levels of sedation according to the Observer's Assessment of Alertness/Sedation

OAA/S score	Responsiveness category	Cp_t of propofol (mcg/mL)	95% CI (mcg/mL)
4	Lethargic response to name spoken in normal tone	1.3 ± 0.33	1.2-1.4
3	Responds only after name is called loudly and or repeatedly	1.7 ± 0.39	1.6-1.8
2	Responds only after mild prodding or shaking	2.0 ± 0.4	1.9-2.1
1	Responds only after squeezing the trapezius	2.4 ± 0.5	2.2-2.5
0	Does not respond after squeezing the trapezius	2.8 ± 0.6	2.6-3.0

Results are presented as mean (±SD).

CI: confidence intervals; Cp_t: plasma concentrations; OAA/S: Observer's Assessment of Alertness/Sedation; SD: standard deviation.

Reprinted by permission from: Springer: Canadian Journal of Anaesthesia. Casati A, Fanelli G, Casaletti E, et al. Clinical assessment of target-controlled infusion of propofol during monitored anesthesia care. Can J Anaesth 1999; 46:235. Copyright © 1999. https://link.springer.com/journal/12630.

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Mean and CI of plasma concentrations of propofol required to obtain each of the different levels of sedation according to the Observer's Assessment of Alertness/Sedation