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Positive predictive value of cell-free fetal DNA screening for fetal trisomies by maternal age

Positive predictive value of cell-free fetal DNA screening for fetal trisomies by maternal age
Maternal age (years) Trisomy 21 Trisomy 18 Trisomy 13
20 48 14 6
25 51 15 7
30 61 21 10
35 79 39 21
40 93 69 50
45 98 90 NA
Data are percentages unless otherwise specified. Positive predictive values were obtained using the NIPT/Cell Free DNA Screening Predictive Value Calculator from the Perinatal Quality Foundation.[1] The calculations are based on prevalence at 16 weeks of gestation using sensitivities and specificities obtained from Gil and colleagues.[2]
NA: not available.
References:
  1. NIPT/Cell Free DNA Screening Predictive Value Calculator from the Perinatal Quality Foundation. Available at: https://www.perinatalquality.org/vendors/nsgc/nipt/ (Retrieved July 21, 2017).
  2. Gil MM, Quezada MS, Revello R, et al. Analysis of cell-free DNA in maternal blood in screening for fetal aneuploidies: updated meta-analysis. Ultrasound Obstet Gynecol 2015; 45:249.

From: Dashe JS. Aneuploidy screening in pregnancy. Obstet Gynecol 2016; 128(1):181-94. DOI: 10.1097/AOG.0000000000001385. Copyright © 2016 American College of Obstetricians and Gynecologists. Reproduced with permission from Lippincott Williams & Wilkins. Unauthorized reproduction of this material is prohibited.

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