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Differentiated and anaplastic thyroid carcinoma TNM staging AJCC UICC 8th edition

Differentiated and anaplastic thyroid carcinoma TNM staging AJCC UICC 8th edition
Primary tumor (T)
Papillary, follicular, poorly differentiated, Hürthle cell and anaplastic thyroid carcinoma
T category T criteria
TX Primary tumor cannot be assessed
T0 No evidence of primary tumor
T1 Tumor ≤2 cm in greatest dimension limited to the thyroid
T1a Tumor ≤1 cm in greatest dimension limited to the thyroid
T1b Tumor >1 cm but ≤2 cm in greatest dimension limited to the thyroid
T2 Tumor >2 cm but ≤4 cm in greatest dimension limited to the thyroid
T3 Tumor >4 cm limited to the thyroid, or gross extrathyroidal extension invading only strap muscles
T3a Tumor >4 cm limited to the thyroid
T3b Gross extrathyroidal extension invading only strap muscles (sternohyoid, sternothyroid, thyrohyoid, or omohyoid muscles) from a tumor of any size
T4 Includes gross extrathyroidal extension beyond the strap muscles
T4a Gross extrathyroidal extension invading subcutaneous soft tissues, larynx, trachea, esophagus, or recurrent laryngeal nerve from a tumor of any size
T4b Gross extrathyroidal extension invading prevertebral fascia or encasing the carotid artery or mediastinal vessels from a tumor of any size
NOTE: All categories may be subdivided: (s) solitary tumor and (m) multifocal tumor (the largest tumor determines the classification).
Regional lymph nodes (N)
N category N criteria
NX Regional lymph nodes cannot be assessed
N0 No evidence of locoregional lymph node metastasis
N0a One or more cytologically or histologically confirmed benign lymph nodes
N0b No radiologic or clinical evidence of locoregional lymph node metastasis
N1 Metastasis to regional nodes
N1a Metastasis to level VI or VII (pretracheal, paratracheal, or prelaryngeal/Delphian, or upper mediastinal) lymph nodes. This can be unilateral or bilateral disease.
N1b Metastasis to unilateral, bilateral, or contralateral lateral neck lymph nodes (levels I, II, III, IV, or V) or retropharyngeal lymph nodes
Distant metastasis (M)
M category M criteria
M0 No distant metastasis
M1 Distant metastasis
Prognostic stage groups
Differentiated
When age at diagnosis is... And T is... And N is... And M is... Then the stage group is...
<55 years Any T Any N M0 I
<55 years Any T Any N M1 II
≥55 years T1 N0/NX M0 I
≥55 years T1 N1 M0 II
≥55 years T2 N0/NX M0 I
≥55 years T2 N1 M0 II
≥55 years T3a/T3b Any N M0 II
≥55 years T4a Any N M0 III
≥55 years T4b Any N M0 IVA
≥55 years Any T Any N M1 IVB
Anaplastic
When T is... And N is... And M is... Then the stage group is...
T1-T3a N0/NX M0 IVA
T1-T3a N1 M0 IVB
T3b Any N M0 IVB
T4 Any N M0 IVB
Any T Any N M1 IVC
TNM: tumor, node, metastasis; AJCC: American Joint Committee on Cancer; UICC: Union for International Cancer Control.
Used with permission of the American College of Surgeons, Chicago, Illinois. The original source for this information is the AJCC Cancer Staging Manual, Eighth Edition (2017) published by Springer International Publishing. Corrected at 4th printing, 2018.
Graphic 110635 Version 9.0

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