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Nasopharyngeal cancer TNM staging AJCC UICC 8th edition

Nasopharyngeal cancer TNM staging AJCC UICC 8th edition
Primary tumor (T)
T category T criteria
TX Primary tumor cannot be assessed
T0 No tumor identified, but EBV-positive cervical node(s) involvement
Tis Tumor in situ
T1 Tumor confined to nasopharynx, or extension to oropharynx and/or nasal cavity without parapharyngeal involvement
T2 Tumor with extension to parapharyngeal space, and/or adjacent soft tissue involvement (medial pterygoid, lateral pterygoid, prevertebreal muscles)
T3 Tumor with infiltration of bony structures at skull base, cervical vertebra, pterygoid structures, and/or paranasal sinuses
T4 Tumor with intracranial extension, involvement of cranial nerves, hypopharynx, orbit, parotid gland, and/or extensive soft tissue infiltration beyond the lateral surface of the lateral pterygoid muscle
Regional lymph nodes (N)
N category N criteria
NX Regional lymph nodes cannot be assessed
N0 No regional lymph node metastasis
N1 Unilateral metastasis in cervical lymph node(s) and/or unilateral or bilateral metastasis in retropharyngeal lymph node(s), 6 cm or smaller in greatest dimension, above the caudal border of cricoid cartilage
N2 Bilateral metastasis in cervical lymph node(s), 6 cm or smaller in greatest dimension, above the caudal border of cricoid cartilage
N3 Unilateral or bilateral metastasis in cervical lymph node(s), larger than 6 cm in greatest dimension, and/or extension below the caudal border of cricoid cartilage
Distant metastasis (M)
M category M criteria
M0 No distant metastasis
M1 Distant metastasis
Prognostic stage groups
When T is... And N is... And M is... Then the stage group is...
Tis N0 M0 0
T1 N0 M0 I
T1, T0 N1 M0 II
T2 N0 M0 II
T2 N1 M0 II
T1, T0 N2 M0 III
T2 N2 M0 III
T3 N0 M0 III
T3 N1 M0 III
T3 N2 M0 III
T4 N0 M0 IVA
T4 N1 M0 IVA
T4 N2 M0 IVA
Any T N3 M0 IVA
Any T Any N M1 IVB
TNM: tumor, node, metastasis; AJCC: American Joint Committee on Cancer; UICC: Union for International Cancer Control; EBV: Epstein-Barr virus.
Used with permission of the American College of Surgeons, Chicago, Illinois. The original source for this information is the AJCC Cancer Staging Manual, Eighth Edition (2017) published by Springer International Publishing. Corrected at 4th printing, 2018.
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