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AJCC 8th edition melanoma TNM definitions

AJCC 8th edition melanoma TNM definitions
Primary tumor (T)
T category Thickness Ulceration status
TX: Primary tumor thickness cannot be assessed (eg, diagnosis by curettage) Not applicable Not applicable
T0: No evidence of primary tumor (eg, unknown primary or completely regressed melanoma) Not applicable Not applicable
Tis (melanoma in situ) Not applicable Not applicable
T1 ≤1.0 mm Unknown or unspecified
T1a <0.8 mm Without ulceration
T1b <0.8 mm With ulceration
0.8 to 1 mm With or without ulceration
T2 >1 to 2 mm Unknown or unspecified
T2a >1 to 2 mm Without ulceration
T2b >1 to 2 mm With ulceration
T3 >2 to 4 mm Unknown or unspecified
T3a >2 to 4 mm Without ulceration
T3b >2 to 4 mm With ulceration
T4 >4 mm Unknown or unspecified
T4a >4 mm Without ulceration
T4b >4 mm With ulceration
Regional lymph nodes (N)
N category Extent of regional lymph node and/or lymphatic metastasis
Number of tumor-involved regional lymph nodes Presence of in-transit, satellite, and/or microsatellite metastases
NX

Regional nodes not assessed (eg, SLN biopsy not performed, regional nodes previously removed for another reason).

Exception: Pathological N category is not required for T1 melanomas, use cN.
No
N0 No regional metastases detected No
N1 One tumor-involved node or in-transit, satellite, and/or microsatellite metastases with no tumor-involved nodes  
N1a One clinically occult (ie, detected by SLN biopsy) No
N1b One clinically detected No
N1c No regional lymph node disease Yes
N2 Two or three tumor-involved nodes or in-transit, satellite, and/or microsatellite metastases with one tumor-involved node  
N2a Two or three clinically occult (ie, detected by SLN biopsy) No
N2b Two or three, at least one of which was clinically detected No
N2c One clinically occult or clinically detected Yes
N3 Four or more tumor-involved nodes or in-transit, satellite, and/or microsatellite metastases with two or more tumor-involved nodes, or any number of matted nodes without or with in-transit, satellite, and/or microsatellite metastases  
N3a Four or more clinically occult (ie, detected by SLN biopsy) No
N3b Four or more, at least one of which was clinically detected, or presence of any number of matted nodes No
N3c Two or more clinically occult or clinically detected and/or presence of any number of matted nodes Yes
Distant metastasis (M)
M category M criteria
Anatomic site LDH level
M0 No evidence of distant metastasis Not applicable
M1 Evidence of distant metastasis See below
M1a Distant metastasis to skin, soft tissue including muscle, and/or nonregional lymph node Not recorded or unspecified
M1a(0) Not elevated
M1a(1) Elevated
M1b Distant metastasis to lung with or without M1a sites of disease Not recorded or unspecified
M1b(0) Not elevated
M1b(1) Elevated
M1c Distant metastasis to non-CNS visceral sites with or without M1a or M1b sites of disease Not recorded or unspecified
M1c(0) Not elevated
M1c(1) Elevated
M1d Distant metastasis to CNS with or without M1a, M1b, or M1c sites of disease Not recorded or unspecified
M1d(0) Normal
M1d(1) Elevated
Suffixes for M category: (0) LDH not elevated, (1) LDH elevated. No suffix is used if LDH is not recorded or is unspecified.
AJCC: American Joint Committee on Cancer; TNM: tumor, node, metastasis; SLN: sentinel lymph node; LDH: lactate dehydrogenase; CNS: central nervous system.
Used with permission of the American College of Surgeons, Chicago, Illinois. The original source for this information is the AJCC Cancer Staging Manual, Eighth Edition (2017) published by Springer International Publishing.
Graphic 110663 Version 11.0

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