AJCC 8th edition melanoma TNM prognostic stage groups

Clinical (cTNM)
Clinical staging includes microstaging of the primary melanoma and clinical/radiologic/biopsy evaluation for metastases. By convention, clinical staging should be used after biopsy of the primary melanoma, with clinical assessment for regional and distant metastases. Note that pathological assessment of the primary melanoma is used for both clinical and pathological classification. Diagnostic biopsies to evaluate possible regional and/or distant metastasis also are included. Note there is only one stage group for clinical Stage III melanoma.
When T is...	And N is...	And M is...	Then the clinical stage group is...
Tis	N0	M0	0
T1a	N0	M0	IA
T1b	N0	M0	IB
T2a	N0	M0	IB
T2b	N0	M0	IIA
T3a	N0	M0	IIA
T3b	N0	M0	IIB
T4a	N0	M0	IIB
T4b	N0	M0	IIC
Any T, Tis	≥N1	M0	III
Any T	Any N	M1	IV
Pathological (pTNM)
Pathological staging includes microstaging of the primary melanoma, including any additional staging information from the wide-excision (surgical) specimen that constitutes primary tumor surgical treatment and pathological information about the regional lymph nodes after SLN biopsy or therapeutic lymph node dissection for clinically evident regional lymph node disease.
When T is...	And N is...	And M is...	Then the pathological stage group is...
Tis	N0	M0	0
T1a	N0	M0	IA
T1b	N0	M0	IA
T2a	N0	M0	IB
T2b	N0	M0	IIA
T3a	N0	M0	IIA
T3b	N0	M0	IIB
T4a	N0	M0	IIB
T4b	N0	M0	IIC
T0	N1b, N1c	M0	IIIB
T0	N2b, N2c, N3b, or N3c	M0	IIIC
T1a/b-T2a	N1a or N2a	M0	IIIA
T1a/b-T2a	N1b/c or N2b	M0	IIIB
T2b/T3a	N1a-N2b	M0	IIIB
T1a-T3a	N2c or N3a/b/c	M0	IIIC
T3b/T4a	Any N ≥N1	M0	IIIC
T4b	N1a-N2c	M0	IIIC
T4b	N3a/b/c	M0	IIID
Any T, Tis	Any N	M1	IV

Pathological Stage 0 (melanoma in situ) and T1 do not require pathological evaluation of lymph nodes to complete pathological staging; use cN information to assign their pathological stage.

AJCC: American Joint Committee on Cancer; TNM: tumor, node, metastasis; SLN: sentinel lymph node.

Used with permission of the American College of Surgeons, Chicago, Illinois. The original source for this information is the AJCC Cancer Staging Manual, Eighth Edition (2017) published by Springer International Publishing.

Graphic 110664 Version 10.0

خرید پکیج

AJCC 8th edition melanoma TNM prognostic stage groups