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Anal cancer TNM staging AJCC UICC 8th edition

Anal cancer TNM staging AJCC UICC 8th edition
Primary tumor (T)
T category T criteria
TX Primary tumor not assessed
T0 No evidence of primary tumor
Tis High-grade squamous intraepithelial lesion (previously termed carcinoma in situ, Bowen disease, anal intraepithelial neoplasia II-III, high-grade anal intraepithelial neoplasia)
T1 Tumor ≤2 cm
T2 Tumor >2 cm but ≤5 cm
T3 Tumor >5 cm
T4 Tumor of any size invading adjacent organ(s), such as the vagina, urethra, or bladder
Regional lymph nodes (N)
N category N criteria
NX Regional lymph nodes cannot be assessed
N0 No regional lymph node metastasis
N1 Metastasis in inguinal, mesorectal, internal iliac, or external iliac nodes
N1a Metastasis in inguinal, mesorectal, or internal iliac lymph nodes
N1b Metastasis in external iliac lymph nodes
N1c Metastasis in external iliac with any N1a nodes
Distant metastasis (M)
M category M criteria
M0 No distant metastasis
M1 Distant metastasis
Prognostic stage groups
When T is... And N is... And M is... Then the stage group is...
Tis N0 M0 0
T1 N0 M0 I
T1 N1 M0 IIIA
T2 N0 M0 IIA
T2 N1 M0 IIIA
T3 N0 M0 IIB
T3 N1 M0 IIIC
T4 N0 M0 IIIB
T4 N1 M0 IIIC
Any T Any N M1 IV
TNM: tumor, node, metastasis; AJCC: American Joint Committee on Cancer; UICC: Union for International Cancer Control.
Used with permission of the American College of Surgeons, Chicago, Illinois. The original source for this information is the AJCC Cancer Staging Manual, Eighth Edition (2017) published by Springer International Publishing.
Graphic 110681 Version 8.0

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