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تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Common combination oral contraceptive options, androgenicity, and associated venous thromboembolic risk of the progestin component

Common combination oral contraceptive options, androgenicity, and associated venous thromboembolic risk of the progestin component
Progestin component Progestin androgenicity Relative VTE risk of COC*[1,2] Absolute VTE risk of COC[1-4] Select formulationsΔ
Norgestimate Neutral or weak androgen 2.5 6 Norgestimate 0.25 mg/ethinyl estradiol 35 mcg:
  • Brand names: Estarylla, Femynor, Mili, Mono-Linyah, Nymyo, Sprintec 28, VyLibra
Drospirenone Antiandrogen 4.1 13 Drospirenone 3 mg/ethinyl estradiol 30 mcg:
  • Brand names: Ocella, Safyral, Syeda, Tydemy, Yasmin, Zumandimine
Levonorgestrel Weak androgen 2.4 6 Levonorgestrel 0.15 mg/ethinyl estradiol 30 mcg:
  • Brand names: Altavera, Ayuna, Chateal EQ, Kurvelo, Levora 0.15/30, Marlissa, Portia-28
Norethindrone (norethisterone) Weak androgen 2.6 7 Norethindrone-containing formulations (mg norethindrone/mg ethinyl estradiol):
  • 0.4 mg/35 mg:
    • Brand names: Balziva, Briellyn, Philith, Vyfemla, Wymzya Fe chewable tablets◊
  • 0.5 mg/35 mcg:
    • Brand names: Necon 0.5/35, Nortrel 0.5/35, Wera
  • 1 mg/35 mcg:
    • Brand names: Alyacen 1/35, Dasetta 1/35, Nortrel 1/35, Nylia 1/35, Pirmella 1/35

 
Norethindrone acetate 1.5 mg/ethinyl estradiol 30 mcg:

  • Brand names: Aurovela 1.5/30, Aurovela Fe 1.5/30◊, Blisovi Fe 1.5/30◊, Junel 1.5/30, Junel FE 1.5/30◊, Hailey 1.5/30, Hailey FE 1.5/30◊, Larin 1.5/30, Larin Fe 1.5/30◊, Loestrin 1.5/30, Loestrin Fe 1.5/30◊, Microgestin 1.5/30, Microgestin FE 1.5/30◊
Desogestrel Neutral 4.3 14 Desogestrel 0.15 mg/ethinyl estradiol 30 mcg:
  • Brand names: Apri, Cyred, Cyred EQ, Enskyce, Isibloom, Juleber, Kalliga, Reclipsen
Gestodene Neutral 3.6 11 Gestodene 0.75 mg/ethinyl estradiol 30 mcg§:
  • Brand names: Akizza, Femodene, Millinette (30/75), Minulet
Cyproterone acetate Antiandrogen 4.3 14 Cyproterone acetate 2 mg/ethinyl estradiol 35 mcg§:
  • Brand names: Cleo-35, Co-ciprindiol, Cyestra-35, Diane-35, Dianette, Estelle
This table presents several COCs along with the androgenicity and VTE risk of their progestin component.

COC: combination oral contraceptive; VTE: venous thromboembolism.

* Relative VTE risk is compared with patients who are not using oral contraceptives.

¶ Extra cases of VTE per 10,000 women treated with COCs per year.

Δ For treatment of polycystic ovary syndrome in adolescents, UpToDate authors prefer COCs with at least 30 mcg of ethinyl estradiol; this table lists a selection of such formulations with example brand names available in the United States. Adults with polycystic ovary syndrome may be managed differently; refer to related UpToDate content. COC formulations with less estrogen, multiphasic combinations, and extended cycle combinations are also available; refer to related UpToDate content.

◊ Packaged with ferrous fumarate instead of inactive (placebo) pills.

§ Not available in the United States; example formulations are available elsewhere in the world. Refer to local prescribing information.
References:
  1. Dragoman MV, Tepper NK, Fu R, et al. A systematic review and meta-analysis of venous thrombosis risk among users of combined oral contraception. Int J Gynecol Obstet 2018; 141: 287-294.
  2. Vinogradova Y, Coupland C, and Hippisley-Cox J. Use of combined oral contraceptives and risk of venous thromboembolism: Nested case-control studies using the QResearch and CPRD databases. BMJ 2015; 350:h2135.
  3. Stegeman BH, de Bastos M, Rosendaal FR, et al. Different combined oral contraceptives and the risk of venous thrombosis: Systematic review and network meta-analysis. BMJ 2013; 347:f5298.
  4. Martin KA, Anderson RR, Chang RJ, et al. Evaluation and treatment of hirsutism in premenopausal women: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2018; 103:1233.
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