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Cancer of the penis TNM staging AJCC UICC 8th edition

Cancer of the penis TNM staging AJCC UICC 8th edition
Primary tumor (T)
T category T criteria
TX Primary tumor cannot be assessed
T0 No evidence of primary tumor
Tis Carcinoma in situ (penile intraepithelial neoplasia [PeIN])
Ta Noninvasive localized squamous cell carcinoma
T1 Glans: Tumor invades lamina propria.
Foreskin: Tumor invades dermis, lamina propria, or dartos fascia.
Shaft: Tumor invades connective tissue between epidermis and corpora regardless of location.
All sites with or without lymphovascular invasion or perineural invasion and is or is not high grade.
T1a Tumor is without lymphovascular invasion or perineural invasion and is not high grade (ie, grade 3 or sarcomatoid)
T1b Tumor exhibits lymphovascular invasion and/or perinerual invasion or is high grade (ie, grade 3 or sarcomatoid)
T2 Tumor invades into corpus spongiosum (either glans or ventral shaft) with or without urethral invasion
T3 Tumor invades into corpora cavernosum (including tunica albuginea) with or without urethral invasion
T4 Tumor invades into adjacent structures (ie, scrotum, prostate, pubic bone)
Regional lymph nodes (N)
Clinical N (cN)
cN category cN criteria
cNX Regional lymph nodes cannot be assessed
cN0 No palpable or visibly enlarged inguinal lymph nodes
cN1 Palpable mobile unilateral inguinal lymph node
cN2 Palpable mobile ≥2 unilateral inguinal nodes or bilateral inguinal lymph nodes
cN3 Palpable fixed inguinal nodal mass or pelvic lymphadenopathy unilateral or bilateral
Pathological N (pN)
pN category pN criteria
pNX Lymph node metastasis cannot be established
pN0 No lymph node metastasis
pN1 ≤2 unilateral inguinal metastases, no ENE
pN2 ≥3 unilateral inguinal metastases or bilateral metastases, no ENE
pN3 ENE of lymph node metastases or pelvic lymph node metastases
Distant metastasis (M)
M category M criteria
M0 No distant metastasis
M1 Distant metastasis present
Prognostic stage groups
When T is... And N is... And M is... Then the stage group is...
Tis N0 M0 0is
Ta N0 M0 0a
T1a N0 M0 I
T1b N0 M0 IIA
T2 N0 M0 IIA
T3 N0 M0 IIB
T1-3 N1 M0 IIIA
T1-3 N2 M0 IIIB
T4 Any N M0 IV
Any T N3 M0 IV
Any T Any N M1 IV
TNM: tumor, node, metastasis; AJCC: American Joint Committee on Cancer; UICC: Union for International Cancer Control; ENE: extranodal extension.
Used with permission of the American College of Surgeons, Chicago, Illinois. The original source for this information is the AJCC Cancer Staging Manual, Eighth Edition (2017) published by Springer International Publishing. Corrected at 4th printing, 2018.
Graphic 110727 Version 10.0

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