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Bladder cancer TNM staging AJCC UICC 8th edition

Bladder cancer TNM staging AJCC UICC 8th edition
Primary tumor (T)
T category T criteria
TX Primary tumor cannot be assessed
T0 No evidence of primary tumor
Ta Noninvasive papillary carcinoma
Tis Urothelial carcinoma in situ: "Flat tumor"
T1 Tumor invades lamina propria (subepithelial connective tissue)
T2 Tumor invades muscularis propria
pT2a Tumor invades superficial muscularis propria (inner half)
pT2b Tumor invades deep muscularis propria (outer half)
T3 Tumor invades perivesical soft tissue
pT3a Microscopically
pT3b Macroscopically (extravesical mass)
T4 Extravesical tumor directly invades any of the following: Prostatic stroma, seminal vesicles, uterus, vagina, pelvic wall, abdominal wall
T4a Extravesical tumor invades directly into prostatic stroma, seminal vesicles, uterus, vagina
T4b Extravesical tumor invades pelvic wall, abdominal wall
Regional lymph nodes (N)
N category N criteria
NX Lymph nodes cannot be assessed
N0 No lymph node metastasis
N1 Single regional lymph node metastasis in the true pelvis (perivesical, obturator, internal and external iliac, or sacral lymph node)
N2 Multiple regional lymph node metastasis in the true pelvis (perivesical, obturator, internal and external iliac, or sacral lymph node metastasis)
N3 Lymph node metastasis to the common iliac lymph nodes
Distant metastasis (M)
M category M criteria
M0 No distant metastasis
M1 Distant metastasis
M1a Distant metastasis limited to lymph nodes beyond the common iliacs
M1b Non-lymph-node distant metastases
Prognostic stage groups
When T is... And N is... And M is... Then the stage group is...
Ta N0 M0 0a
Tis N0 M0 0is
T1 N0 M0 I
T2a N0 M0 II
T2b N0 M0 II
T3a, T3b, T4a N0 M0 IIIA
T1-T4a N1 M0 IIIA
T1-T4a N2, N3 M0 IIIB
T4b Any N M0 IVA
Any T Any N M1a IVA
Any T Any N M1b IVB
TNM: tumor, node, metastasis; AJCC: American Joint Committee on Cancer; UICC: Union for International Cancer Control.
Used with permission of the American College of Surgeons, Chicago, Illinois. The original source for this information is the AJCC Cancer Staging Manual, Eighth Edition (2017) published by Springer International Publishing. Corrected at 4th printing, 2018.
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