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Choroidal and ciliary body melanoma TNM staging AJCC UICC 8th edition

Choroidal and ciliary body melanoma TNM staging AJCC UICC 8th edition
Primary tumor (T)
T category T criteria
TX Primary tumor cannot be assessed
T0 No evidence of primary tumor
T1 Tumor size category 1
T1a Tumor size category 1 without ciliary body involvement and extraocular extension
T1b Tumor size category 1 with ciliary body involvement
T1c Tumor size category 1 without ciliary body involvement but with extraocular extension ≤5 mm in largest diameter
T1d Tumor size category 1 with ciliary body involvement and extraocular extension ≤5 mm in largest diameter
T2 Tumor size category 2
T2a Tumor size category 2 without ciliary body involvement and extraocular extension
T2b Tumor size category 2 with ciliary body involvement
T2c Tumor size category 2 without ciliary body involvement but with extraocular extension ≤5 mm in largest diameter
T2d Tumor size category 2 with ciliary body involvement and extraocular extension ≤5 mm in largest diameter
T3 Tumor size category 3
T3a Tumor size category 3 without ciliary body involvement and extraocular extension
T3b Tumor size category 3 with ciliary body involvement
T3c Tumor size category 3 without ciliary body involvement but with extraocular extension ≤5 mm in largest diameter
T3d Tumor size category 3 with ciliary body involvement and extraocular extension ≤5 mm in largest diameter
T4 Tumor size category 4
T4a Tumor size category 4 without ciliary body involvement and extraocular extension
T4b Tumor size category 4 with ciliary body involvement
T4c Tumor size category 4 without ciliary body involvement but with extraocular extension ≤5 mm in largest diameter
T4d Tumor size category 4 with ciliary body involvement and extraocular extension ≤5 mm in largest diameter
T4e Any tumor size category with extraocular extension >5 mm in largest diameter
NOTES:
  1. Primary ciliary body and choroidal melanomas are classified according to the four tumor size categories defined in figure entitled "Classification for ciliary body and choroid uveal melanoma based on thickness and diameter."
  2. In clinical practice, the largest tumor basal diameter may be estimated in optic disc diameters (DD; average: 1 DD = 1.5 mm), and tumor thickness may be estimated in diopters (average: 2.5 diopters = 1 mm). Ultrasonography and fundus photography are used to provide more accurate measurements.
  3. When histopathologic measurements are recorded after fixation, tumor diameter and thickness may be underestimated because of tissue shrinkage.
Classification for ciliary body and choroid uveal melanoma based on thickness and diameter
  Largest basal diameter (mm)
Thickness (mm) ≤3.0 3.1 to 6.0 6.1 to 9.0 9.1 to 12.0 12.1 to 15.0 15.1 to 18.0 >18.0
>15.0         4 4 4
12.1 to 15.0       3 3 4 4
9.1 to 12.0   3 3 3 3 3 4
6.1 to 9.0 2 2 2 2 3 3 4
3.1 to 6.0 1 1 1 2 2 3 4
≤3.0 1 1 1 1 2 2 4
 
Regional lymph nodes (N)
N category N criteria
NX Regional lymph nodes cannot be assessed
N0 No regional lymph node involvement
N1 Regional lymph node metastases or discrete tumor deposits in the orbit
N1a Metastasis in one or more regional lymph node(s)
N1b No regional lymph nodes are positive, but there are discrete tumor deposits in the orbit that are not contiguous to the eye (choroidal and ciliary body)
Distant metastasis (M)
M category M criteria
M0 No distant metastasis by clinical classification
M1 Distant metastasis
M1a Largest diameter of the largest metastasis ≤3.0 cm
M1b Largest diameter of the largest metastasis 3.1-8.0 cm
M1c Largest diameter of the largest metastasis ≥8.1 cm
Prognostic stage groups
When T is... And N is... And M is... Then the stage group is...
T1a N0 M0 I
T1b-d N0 M0 IIA
T2a N0 M0 IIA
T2b N0 M0 IIB
T3a N0 M0 IIB
T2c-d N0 M0 IIIA
T3b-c N0 M0 IIIA
T4a N0 M0 IIIA
T3d N0 M0 IIIB
T4b-c N0 M0 IIIB
T4d-e N0 M0 IIIC
Any T N1 M0 IV
Any T Any N M1a-c IV
TNM: tumor, node, metastasis; AJCC: American Joint Committee on Cancer; UICC: Union for International Cancer Control.
Used with permission of the American College of Surgeons, Chicago, Illinois. The original source for this information is the AJCC Cancer Staging Manual, Eighth Edition (2017) published by Springer International Publishing. Corrected at 4th printing, 2018.
Graphic 110766 Version 10.0

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