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Urethral cancer TNM staging AJCC UICC 8th edition

Urethral cancer TNM staging AJCC UICC 8th edition
Primary tumor (T)
Male penile urethra and female urethra
T category T criteria
TX Primary tumor cannot be assessed
T0 No evidence of primary tumor
Ta Non-invasive papillary carcinoma
Tis Carcinoma in situ
T1 Tumor invades subepithelial connective tissue
T2 Tumor invades any of the following: Corpus spongiosum, periurethral muscle
T3 Tumor invades any of the following: Corpus cavernosum, anterior vagina
T4 Tumor invades other adjacent organs (eg, invasion of the bladder wall)
Prostatic urethra
T category T criteria
TX Primary tumor cannot be assessed
T0 No evidence of primary tumor
Ta Non-invasive papillary carcinoma
Tis Carcinoma in situ involving the prostatic urethra or periurethral or prostatic ducts without stromal invasion
T1 Tumor invades urethral subepithelial connective tissue immediately underlying the urothelium
T2 Tumor invades the prostatic stroma surrounding ducts either by direct extension from the urothelial surface or by invasion from prostatic ducts
T3 Tumor invades the periprostatic fat
T4 Tumor invades other adjacent organs (eg, extraprostatic invasion of the bladder wall, rectal wall)
Regional lymph nodes (N)
N category N criteria
NX Regional lymph nodes cannot be assessed
N0 No regional lymph node metastasis
N1 Single regional lymph node metastasis in the inguinal region or true pelvis (perivesical, obturator, internal [hypogastric] and external iliac), or presacral lymph node
N2 Multiple regional lymph node metastasis in the inguinal region or true pelvis (perivesical, obturator, internal [hypogastric] and external iliac), or presacral lymph node
Distant metastasis (M)
M category M criteria
M0 No distant metastasis
M1 Distant metastasis
Prognostic stage groups
When T is... And N is... And M is... Then the stage group is...
Tis N0 M0 0is
Ta N0 M0 0a
T1 N0 M0 I
T1 N1 M0 III
T2 N0 M0 II
T2 N1 M0 III
T3 N0 M0 III
T3 N1 M0 III
T4 N0 M0 IV
T4 N1 M0 IV
Any T N2 M0 IV
Any T Any N M1 IV
TNM: tumor, node, metastasis; AJCC: American Joint Committee on Cancer; UICC: Union for International Cancer Control.
Used with permission of the American College of Surgeons, Chicago, Illinois. The original source for this information is the AJCC Cancer Staging Manual, Eighth Edition (2017) published by Springer International Publishing. Corrected at 4th printing, 2018.
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