Risk profile and associated survival outcomes, MD Anderson validation of biomarkers in TNM 8th edition staging

	Five-year DSS (%)	Univariate analysis		Multivariate analysis 2		Assigned points
	Five-year DSS (%)	HR	p	HR	p	Assigned points
Pathological stage
I	99.1	Referent		Referent		0
IIA	98.0	2.8	0.002	2.3	0.01	1
IIB	95.6	4.8	<0.0001	4.0	<0.0001	2
IIIA	95.4	6.8	<0.0001	7.2	<0.0001	3
IIIC	79.5	26.6	<0.0001	19.9	<0.0001	4
Nuclear grade
I	99.8	Referent		Referent		0
II	98.9	5.0	0.1	4.0	0.2	0
III	95.3	25.0	0.001	13.1	0.01	1
ER status
Positive	98.8	Referent		Referent		0
Negative	92.9	4.9	<0.0001	2.5	0.001	1
PR status
Positive	98.8	Referent		Referent
Negative	95.2	4.0	<0.0001		NS
HER2 status
Positive	97.5	Referent		Referent		0
Negative	98.0	0.8	0.5	2.2	0.04	1
Factor	0 points			1 point
Grade	Grade 1/2			Grade 3
ER status	ER positive			ER negative
HER2 status	HER2 positive			HER2 negative
Stage	Risk profile	N	Five-year DSS (%)	95% CI	Five-year OS (%)	95% CI
I (IA and IB)	0	36	100		97	80.4-99.6
	1	1173	99.4	98.7-99.7	96.7	95.4-97
	2	274	98.8	96.4-99.6	94.6	91-96.8
	3	119	96.6	91.1-98.7	93.8	87.5-97
IIA	0	31	100		96.8	79.2-99.5
	1	634	99.4	97.5-99.8	97.1	94.7-98.4
	2	236	97.5	93.2-99.1	94.1	88.7-97
	3	98	91	81.8-95.7	88.2	78.5-93.8
IIB	0	11	100		100
	1	309	96.9	92.6-98.8	94.6	89.6-97.2
	2	107	92.9	83.6-97.1	89.3	80.1-94.4
	3	40	91.5	75.6-97.2	91.5	75.6-97.2
IIIA	0	3	100		100
	1	134	98.3	88.2-99.8	91.5	82.6-96
	2	50	92.2	77.2-97.5	90.3	75.7-96.3
	3	7	68.6	21.3-91.2	68.6	21.3-91.2
IIIC	0	0
	1	39	92.2	72.1-98.0	84.4	63.7-93.9
	2	16	80.8	51.4-93.4	80.8	51.4-93.4
	3	10	33.3	6.3-64.6	33.3	6.3-64.6

TNM: tumor, node, metastasis; AJCC: American Joint Committee on Cancer.

Used with permission of the American College of Surgeons, Chicago, Illinois. The original source for this information is the AJCC Cancer Staging Manual, Eighth Edition (2017) published by Springer International Publishing.

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Risk profile and associated survival outcomes, MD Anderson validation of biomarkers in TNM 8th edition staging