Primary tumor (T) | |||
T category | T criteria | ||
TX | Primary tumor cannot be assessed | ||
T0 | No evidence of primary tumor | ||
Tis | Carcinoma in situ | ||
T1 | Tumor invades the lamina propria or muscular layer | ||
T1a | Tumor invades the lamina propria | ||
T1b | Tumor invades the muscular layer | ||
T2 | Tumor invades the perimuscular connective tissue on the peritoneal side, without involvement of the serosa (visceral peritoneum). Or tumor invades the perimuscular connective tissue on the hepatic side, with no extension into the liver. | ||
T2a | Tumor invades the perimuscular connective tissue on the peritoneal side, without involvement of the serosa (visceral peritoneum) | ||
T2b | Tumor invades the perimuscular connective tissue on the hepatic side, with no extension into the liver | ||
T3 | Tumor perforates the serosa (visceral peritoneum) and/or directly invades the liver and/or one other adjacent organ or structure, such as the stomach, duodenum, colon, pancreas, omentum, or extrahepatic bile ducts | ||
T4 | Tumor invades the main portal vein or hepatic artery or invades two or more extrahepatic organs or structures | ||
Regional lymph nodes (N) | |||
N category | N criteria | ||
NX | Regional lymph nodes cannot be assessed | ||
N0 | No regional lymph node metastasis | ||
N1 | Metastases to one or three regional lymph nodes | ||
N2 | Metastases to four or more regional lymph nodes | ||
Distant metastasis (M) | |||
M category | M criteria | ||
M0 | No distant metastasis | ||
M1 | Distant metastasis | ||
Prognostic stage groups | |||
When T is... | And N is... | And M is... | Then the stage group is... |
Tis | N0 | M0 | 0 |
T1 | N0 | M0 | I |
T2a | N0 | M0 | IIA |
T2b | N0 | M0 | IIB |
T3 | N0 | M0 | IIIA |
T1-3 | N1 | M0 | IIIB |
T4 | N0-1 | M0 | IVA |
Any T | N2 | M0 | IVB |
Any T | Any N | M1 | IVB |
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