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Scoring guidelines for the interpretation of HER2 immunohistochemical staining (IHC) in esophagogastric adenocarcinoma

Scoring guidelines for the interpretation of HER2 immunohistochemical staining (IHC) in esophagogastric adenocarcinoma
Surgical specimen-staining pattern Biopsy specimen-staining pattern Score HER2 expression assessment
No reactivity or membranous reactivity in <10% of tumor cells No reactivity or no membranous reactivity in any tumor cell 0 Negative
Faint/barely perceptible membranous reactivity in ≥10% of tumor cells; cells are reactive only in part of their membrane Tumor cell cluster* with a faint/barely perceptible membranous reactivity irrespective of percentage of tumor cells stained 1+ Negative
Weak to moderate, complete, basolateral or lateral membranous reactivity in ≥10% of tumor cells Tumor cell cluster* with a weak to moderate, complete, basolateral or lateral membranous reactivity irrespective of percentage of tumor cells stained 2+ Equivocal
Strong, complete, basolateral or lateral membranous reactivity in ≥10% of tumor cells Tumor cell cluster* with a strong, complete, basolateral or lateral membranous reactivity irrespective of percentage of tumor cells stained 3+ Positive
HER2: human epidermal growth factor receptor 2.
* Tumor cell cluster (5 neoplastic cells).
Original table published in Hofmann M, Stoss O, Shi D, et al. Assessment of a HER2 scoring system for gastric cancer: results from a validation study. Histopathology 2008; 52:797. http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1365-2559.2008.03028.x/abstract. Copyright © 2008. Reproduced with permission of John Wiley & Sons Inc. This image has been provided by or is owned by Wiley. Further permission is needed before it can be downloaded to PowerPoint, printed, shared or emailed. Please contact Wiley's permissions department either via email: [email protected] or use the RightsLink service by clicking on the 'Request Permission' link accompanying this article on Wiley Online Library (http://onlinelibrary.wiley.com).
Modified table reprinted from Bartley AN, Washington MK, Ventura CB, et al. HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma: Guideline From the College of American Pathologists, American Society for Clinical Pathology, and American Society of Clinical Oncology. Arch Pathol Lab Med 2016; 140(12):1345-1363. From Archives of Pathology & Laboratory Medicine. Copyright 2016 College of American Pathologists.
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