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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 1 مورد

Prophylaxis for postoperative nausea and vomiting (PONV) in adults

Prophylaxis for postoperative nausea and vomiting (PONV) in adults
For further information, refer to UpToDate content on postoperative nausea and vomiting.

5HT: 5 hydroxytryptamine; PONV: postoperative nausea and vomiting; TIVA: total intravenous anesthesia.

* The choice of PONV prophylaxis must take into account the medical and surgical risks of PONV (eg, disruption of surgical repair, increase in intracranial pressure) and patient and provider preferences.

¶ A variety of antiemetics acting via different mechanisms are used for PONV prophylaxis.
  • Choice of agents is based upon side effect profile, personal experience, cost, and formulary considerations
  • Commonly used antiemetics and categories include:
    • 5HT receptor antagonists (eg, ondansetron)
    • Dexamethasone
    • Scopolamine transdermal
    • Neurokinin receptor antagonists (eg, aprepitant)
    • Antihistamines (eg, dimenhydrinate or diphenhydramine)
    • Antidopaminergics (eg, haloperidol)
  • When more than 1 antiemetic is administered, drugs from different classes should be chosen as the beneficial effects of antiemetics that act on different receptors are additive.

Δ Many clinicians offer PONV prophylaxis with ≥1 antiemetic to low-risk patients.

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