Hyperkeratotic conditions: Topical: Apply 1 to 3 times daily.
Refer to adult dosing.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Frequency not defined.
Central nervous system: Transient stinging of the skin
Dermatologic: Burning sensation of skin (transient), pruritus (transient)
Local: Local irritation
Clinically significant hypersensitivity to urea or any component of the formulation
OTC labeling: When used for self-medication, do not use on irritated, infected, or open skin.
Concerns related to adverse effects:
• Skin reactions: Some products may cause photosensitivity. Use skin protection and limit sun exposure during therapy and for one week after.
Other warnings/precautions:
• Appropriate use: Avoid contact with eyes, lips, and mucous membranes. Discontinue use if redness, discomfort, or irritation occurs.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Cream, External:
DermacinRx Urea: 41% (227 g) [contains cetyl alcohol, methylparaben, propylene glycol]
Gordons Urea: 40% (120 g) [contains cetyl alcohol, methylparaben, propylene glycol, propylparaben, trolamine (triethanolamine)]
Gormel: 20% (75 g, 120 g, 480 g, 2400 g) [contains cetyl alcohol, methylparaben, propylene glycol, propylparaben, trolamine (triethanolamine)]
Keralac: 47% (142 g [DSC]) [contains edetate (edta) disodium, menthol]
Mycocide CX Callus Exfoliator: 12% (100 mL) [contains methylparaben, propylene glycol, propylparaben]
Nutraplus: 10% (85 g, 453 g) [odorless; contains cetearyl alcohol, methylparaben, propylene glycol, propylparaben]
Protexa: 42% (45 g [DSC]) [contains cetearyl alcohol, propylene glycol]
Rea-Lo: 30% (227 g [DSC], 59 mL [DSC])
Urea 20 Intensive Hydrating: 20% (85 g) [contains cetyl alcohol, propylene glycol, trolamine (triethanolamine)]
Urea 20 Intensive Hydrating: 20% (85 g) [contains propylene glycol]
Ureacin-20: 20% (113.4 g)
Uredeb: 39% (227 g) [contains butylparaben, cetyl alcohol, ethylparaben, isobutylparaben, methylparaben, propylene glycol, propylparaben]
Uremez-40: 40% (227 g) [contains butylparaben, cetyl alcohol, ethylparaben, isobutylparaben, methylparaben, propylene glycol, propylparaben]
Uresol: 42.5% (227 g) [contains butylparaben, cetyl alcohol, ethylparaben, isobutylparaben, methylparaben, propylene glycol, propylparaben]
Urevaz: 44% (60 g [DSC]) [contains cetyl alcohol, disodium edta, propylene glycol]
Utopic: 41% (227 g [DSC]) [contains cetyl alcohol, propylene glycol]
Xurea: 39% (227 g) [contains propylene glycol, trolamine (triethanolamine)]
Generic: 10% (85 g); 20% (85 g); 40% (28 g, 28.35 g, 85 g, 198 g, 198.4 g); 41% (227 g); 45% (255 g); 47% (142 g); 39% (226.8 g, 227 g)
Foam, External:
Hydro 40: 40% (150 g) [contains ethylparaben, methylparaben, propylene glycol, propylparaben, trolamine (triethanolamine)]
Umecta Mousse: 40% (113.4 g) [contains soya sterol, trolamine (triethanolamine)]
Urea Hydrating: 35% (150 g) [contains ethylparaben, methylparaben, propylene glycol, propylparaben, trolamine (triethanolamine)]
Generic: 35% (227 g)
Gel, External:
Uramaxin: 45% (28 mL) [contains edetate (edta) disodium, menthol, propylene glycol]
Urea Nail: 45% (28 mL) [contains edetate (edta) disodium, menthol, propylene glycol]
Lotion, External:
Beta Care Betamide: 25% (120 mL, 480 mL)
Cerovel: 40% (325 mL) [contains alcohol, usp, trolamine (triethanolamine)]
Dermal Therapy Finger Care: 20% (18 mL)
Gormel 10: 10% (228 g)
Nutraplus: 10% (236 mL, 473 mL) [odorless; contains methylparaben, propylparaben]
Ultra Mide 25: 25% (236 mL) [paraben free; contains cetyl alcohol, edetate (edta) sodium (tetrasodium)]
Urea-C40: 40% (236.6 mL [DSC])
Ureacin-10: 10% (236.56 mL)
Generic: 10% (177 mL, 236 mL); 20% (177 mL [DSC]); 40% (226.8 g)
Ointment, External:
Aquaphilic/Carbamide: 10% (180 g, 454 g); 20% (454 g)
Lanaphilic/Urea: 10% (454 g); 20% (454 g)
Solution, External:
CEM-Urea: 45% (20 mL) [contains edetate (edta) disodium, menthol, methylparaben, propylene glycol]
Suspension, External:
Generic: 40% (283.4 g [DSC])
May be product dependent
Cream (DermacinRx Urea External)
41% (per gram): $17.41
Cream (Nutraplus External)
10% (per gram): $0.17
Cream (Urea External)
10% (per gram): $0.11
20% (per gram): $0.14
39% (per gram): $1.54
40% (per gram): $0.24 - $2.57
41% (per gram): $3.60
45% (per gram): $0.67
47% (per gram): $4.52
Cream (Uredeb External)
39% (per gram): $16.49
Cream (Uresol External)
42.5% (per gram): $19.92
Foam (Hydro 40 External)
40% (per gram): $1.66
Foam (Umecta Mousse External)
40% (per gram): $2.81
Foam (Urea External)
35% (per gram): $13.95
Gel (Uramaxin External)
45% (per mL): $11.35
Lotion (Beta Care Betamide External)
25% (per mL): $0.06
Lotion (Cerovel External)
40% (per mL): $0.29
Lotion (Dermal Therapy Finger Care External)
20% (per mL): $0.30
Lotion (Nutraplus External)
10% (per mL): $0.07
Lotion (Ultra Mide 25 External)
25% (per mL): $0.12
Lotion (Urea External)
10% (per mL): $0.09
40% (per gram): $0.82 - $0.98
Ointment (Aquaphilic/Carbamide External)
10% (per gram): $0.04
20% (per gram): $0.03
Ointment (Lanaphilic/Urea External)
10% (per gram): $0.03
20% (per gram): $0.03
Solution (CEM-Urea External)
45% (per mL): $13.98
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
Apply to affected area; rub in until completely absorbed. May cover with adhesive bandage/gauze or plastic film. Shake lotion, foam, and suspension vigorously before administering dose.
Hyperkeratotic conditions: Debridement and promotion of normal healing of hyperkeratotic surface lesions, particularly where healing is retarded by local infection, necrotic tissue, fibrinous or purulent debris, or eschar; treatment of hyperkeratotic conditions, such as dry, rough skin; skin cracks and fissures; dermatitis; psoriasis; xerosis; ichthyosis; eczema; keratosis; keratoderma; corns and calluses; damaged, ingrown, and devitalized nails.
None known.
There are no known significant interactions.
Reproduction studies have not been conducted with all products. When conducted, adverse events were not observed in animal studies.
It is not known if urea is found in breast milk. The manufacturer recommends caution be used if administered to nursing women.
Urea softens hyperkeratotic areas by dissolving the intracellular matrix, resulting in loosening the horny layer of the skin, or softening and debridement of the nail plate
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