Diagnostic approach to the neonate and infant with generalized nonbullous, scaly erythroderma

SCID: severe combined immunodeficiency; GVHD: graft-versus-host disease; IgE: immunoglobulin E; SPINK5: serine peptidase inhibitor, Kazal type 5; RAG1 and RAG2: recombinase-activating genes 1 and 2; DOCK8: dedicator of cytokinesis 8; STAT3: signal transducer and activator of transcription 3; FISH: fluorescence in situ hybridization.
* In the United States and in several countries in Europe, Asia, and Australia, newborn screening is performed for primary immunodeficiencies and several metabolic diseases.