Potential clinical significance of fever pattern*

Pattern	Description	Possible causes
Intermittent (also called hectic or spiking)	High spike and rapid defervescence	Pyogenic infection (most common) Tuberculosis Lymphoma JIA
Remittent^¶	Fluctuating peaks, but baseline remains elevated	Viral infections (most common) Bacterial infection (particularly infective endocarditis) Sarcoidosis Lymphoma Atrial myxoma
Sustained^¶	Little or no fluctuation	Typhoid fever Typhus Brucellosis Other infections
Relapsing	Febrile episodes followed by afebrile periods of ≥1 day	Malaria Rat-bite fever Borrelia infection (eg, tick-borne relapsing fever and louse-borne relapsing fever) Lymphoma
Recurrent	Recurrent episodes of fever over ≥6 months' duration	Metabolic defects CNS dysregulation of temperature control Periodic disorders Cyclic neutropenia Hyperimmunoglobulin D syndrome PFAPA Deficiency of IL-1 or IL-36 receptor antagonist Immunodeficiency

JIA: juvenile idiopathic arthritis; CNS: central nervous system; PFAPA: periodic fever with aphthous stomatitis, pharyngitis, and adenitis; IL: interleukin.
* The fever pattern is best documented by asking the family to keep a fever diary.
¶ May appear to be intermittent if antipyretic agents are administered.

Graphic 111290 Version 1.0

خرید پکیج

Potential clinical significance of fever pattern*