Estimates of the benefit of adjuvant chemotherapy in responders versus nonresponders after chemoradiotherapy for rectal cancer, from an analysis of five European randomized trials

Estimates at five years	Responders (ie, ypT0N0)		Nonresponders (ie, ypT3N1)
Estimates at five years	Adjuvant chemo negative	Adjuvant chemo positive	Adjuvant chemo negative	Adjuvant chemo positive
Local recurrence risk (%)	3	2	20	12
Distant metastasis risk (%)	11	9	51	36
Death (%)	11.5	9.5	68	57

Data from: Valentini V, van Stiphout RG, Lammering G, et al. Nomograms for predicting local recurrence, distant metastases, and overall survival for patients with locally advanced rectal cancer on the basis of European randomized clinical trials. J Clin Oncol 2011; 29:3163.

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