Version July 2025
| Hyperandrogenism (females) and hypogonadism |
| Hirsutism |
| Diminished libido |
| Oligo- or amenorrhea |
| Acne |
| Female balding |
| Metabolic |
| Progressive weight gain |
| Central obesity |
| Facial rounding |
| Dorsal fat pad |
| Impaired glucose tolerance |
| Skin and musculoskeletal |
| Ecchymoses |
| Facial plethora |
| Striae (>1 cm wide, often violaceous) |
| Proximal muscle weakness |
| Back pain |
| Low bone mineral density |
| Fragility fracture |
| Cardiovascular |
| Hypertension |
| Peripheral edema |
| Atherosclerotic cardiovascular disease |
| Neuropsychiatric |
| Depressive symptoms or major depression |
| Emotional lability |
| Impaired cognition (eg, short-term memory deficits) |
| Headache |
| Other |
| Fatigue |
| Abdominal pain |
| Immunocompromise with recurrent infections |
