Version May 2024
| Tumor type | CNS WHO grade | Characteristic molecular genetic alterations |
| Medulloblastomas, molecularly defined | ||
| Medulloblastoma, WNT-activated | 4 | WNT pathway genes |
| Medulloblastoma, SHH-activated and TP53-wildtype | 4 | SHH pathway genes, TP53 |
| Medulloblastoma, SHH-activated and TP53-mutant | 4 | Methylome |
| Medulloblastoma, non-WNT/non-SHH | 4 | |
| Medulloblastomas, histologically defined | ||
| Medulloblastoma, histologically defined | 4 | |
| Other CNS embryonal tumors | ||
| Atypical teratoid/rhabdoid tumor | 4 | SMARCB1, SMARCA4 |
| Cribriform neuroepithelial tumor* | NA | SMARCB1 |
| Embryonal tumor with multilayered rosettes | 4 | C19MC, DICER1 |
| CNS neuroblastoma, FOXR2-activated | 4 | FOXR2 |
| CNS tumor with BCOR internal tandem duplication | NA | BCOR |
| CNS embryonal tumor NEC/NOS | NA | |
WHO: World Health Organization; CNS: central nervous system; WNT: Wingless; SHH: sonic hedgehog; TP53: tumor protein p53; NA: not assigned; SMARC: SWI/SNF related matrix-associated actin-dependent regulator of chromatin; C19MC: chromosome 19 microRNA cluster; FOXR2: forkhead box R2; BCOR: BCL6 corepressor; NEC: not elsewhere classified; NOS: not otherwise specified.
* Provisional tumor.آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟
