Criteria | Description |
a | Total cholesterol concentration above 7.5 mmol/liter (290 mg/dL) in adults or a total cholesterol concentration above 6.7 mmol/liter (259 mg/dL) in children aged less than 16 years, or |
Low-density lipoprotein cholesterol concentration above 4.9 mmol/liter (189 mg/dL) in adults or above 4.0 mmol/liter (155 mg/dL) in children | |
b | Tendinous xanthomata in the patient or a first-degree relative |
c | DNA-based evidence of mutation in the LDLR, PCSK9, or APOB gene |
d | Family history of myocardial infarction before age 50 years in a second-degree relative or before age 60 years in a first-degree relative |
e | Family history of raised total cholesterol concentration above 7.5 mmol/liter (290 mg/dL) in a first- or second-degree relative |
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