Selection criteria for uterus transplant recipient and donor

Criteria	Recipient	Donor
Age
	38 years or younger	Less than 60 years
Body mass index (kg/m²)
	20 to 29	20 to 29
Medication
	None	None
Menopause status
	Premenopausal	No more than seven years postmenopause
History
Medical	No prior malignancy	No prior malignancy
	No hypertension or cardiovascular disease	No hypertension or cardiovascular disease
	No diabetes	No diabetes
	No lung disease (including asthma and COPD)	No lung disease (including asthma and COPD)
	No thromboembolic disorders	No thromboembolic disorders
	Normal renal function	Normal bilateral kidneys (not pelvic)
Psychiatric	No prior hospitalization for psychiatric illness	No prior hospitalization for psychiatric illness
Gynecologic	No history of human papillomavirus infection	No history of human papillomavirus infection
Uterus	Absent (congenital or surgical)	No present or past lesions, except myoma can be present if <2 cm*
Uterus	Present, but clear absolute uterine factor infertility^¶	Present, but clear absolute uterine factor infertility^¶
Vagina	Vaginal length >7 cm	N/A
Vagina	No intestinal neovagina	N/A
Ovaries	N/A	N/A
Obstetric history	N/A	At least one prior normal term delivery
		No more than one prior cesarean delivery (through the lower uterine segment)
		No prior preterm deliveries
		No prior preeclampsia No history of recurrent miscarriage
Surgical history	No prior major intra-abdominal surgery	No prior major intra-abdominal surgery^Δ
Substance use	Non-smoker	Non-smoker
Relationship status	Stable partnership >2 years' duration	N/A
Tests
Blood group	Compatibility with donor	Compatibility with recipient
Human leukocyte antigen	Reasonable match with donor	Reasonable match with recipient
Laboratory blood tests (complete blood count, metabolic panel, coagulation studies)	Normal	Normal
Human immunodeficiency virus	Negative	Negative
Human T-lymphotrophic virus polymerase-chain reaction testing for pro-viral DNA	Negative	Negative
Hepatitis B and C testing	Negative	Negative
Syphilis	Negative	Negative
Chlamydia	Negative	Negative
Gonorrhea	Negative	Negative
Cervical cytology	N/A	Normal
Human papillomavirus high-risk DNA testing	Negative	Negative
Imaging
Renal ultrasound	Non-pelvic kidneys	Normal bilateral, non-pelvic kidneys
Abdominal-pelvic magnetic resonance imaging	Normal	Normal
Chest radiograph	Normal	Normal
Electrocardiography	Normal	Normal
Exercise electrocardiography	N/A	Normal
Angiography of uterus	N/A	Uterine artery diameter >2 mm at level of lower uterine segment
In vitro fertilization	Greater than 8 normal embryos cryopreserved	N/A

COPD: chronic obstructive pulmonary disease; N/A: not applicable.
* Includes adenomyosis, polyps, dysplasia, or conization.
¶ Examples include hypoplastic uterus, major uterine malformation, or severe intrauterine adhesions.
Δ Excludes cesarean delivery.

Graphic 111793 Version 4.0

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Selection criteria for uterus transplant recipient and donor