Clinical and histologic features of the subtypes of localized lichen myxedematosus

Disease	Main clinical features	Main histologic features
Acral persistent papular mucinosis	Symmetrical papules on the extensor surface of the hands, wrists, and sometimes forearms; not self-healing; without systemic involvement	Focal deposits of mucin in upper reticular dermis sparing a subepidermal area, no increase in the number of fibroblasts
Discrete papular LM	Papules on trunk and limbs, not self-healing, with symmetrical or asymmetrical pattern, and without systemic involvement	Mucin deposits between collagen bundles in the reticular dermis with variable fibroblast proliferation
Cutaneous (papular) mucinosis of infancy	Congenital or perinatal, firm papules, not self-healing, without systemic involvement	Papillary dermal mucin, without overt fibroblast proliferation
Nodular LM	Nodules with slight or absent papules, not self-healing, without systemic involvement	Mucin in the reticular dermis
Localized LM with monoclonal gammopathy	Features of localized LM, monoclonal gammopathy	Mucin deposition with variable fibroblast proliferation
Localized LM with mixed features of different subtypes	Mixed features of two or more kinds of localized LM	Mucin deposition with variable fibroblast proliferation

LM: lichen myxedematosus.

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