Version June 2024
| Disorder | Clinical findings |
| Aquagenic palmoplantar keratoderma | Asymptomatic, translucent white papules or plaques on the palms and/or soles that appear after brief exposure to water; clinical findings disappear after drying within minutes to hours. |
| Arsenical keratosis | Multiple, asymptomatic, hard, corn-like papules on the palms and soles; papules may coalesce to form verrucous plaques. |
| Basal cell nevus syndrome | Palmar or plantar pits; other features of the syndrome (eg, basal cell carcinomas, odontogenic keratocysts, rib abnormalities, calcification of the falx cerebri). |
| Darier disease | Hyperkeratotic papules and centrally depressed pits on palms and soles; associated yellow-brown or brown hyperkeratotic papules and plaques in seborrheic areas, nail changes (red longitudinal stripes with a peripheral notch or split). |
| Dyshidrotic eczema | Pruritic, tense, deep-seated vesicles on palms and/or soles, especially on lateral aspect of digits. |
| Exfoliative keratolysis | Air-filled blisters/bullae on an erythematous base and superficial desquamation leaving collarettes of scale. |
| Focal acral hyperkeratosis | Small, yellow to white keratotic papules on the palms and soles preferentially located on plantar and palmar margins; may coalesce to form plaques. |
| Juvenile plantar dermatosis | Erythema, hyperkeratosis, and fissures on plantar surfaces of toes and anterior soles of the feet in children; bilateral distribution. |
| Plantar warts | Firm, rough papules that may coalesce into a mosaic plaque; thrombosed capillaries visible, particularly after paring of stratum corneum. |
| Porokeratosis | Punctate porokeratosis: Multiple seed-like keratotic lesions with thin, raised margins and/or pits on palms and soles. Porokeratosis palmaris et plantaris disseminata: Small, uniform macules on palms and soles with slightly raised peripheral ridge and atrophic center. |
| Punctate palmoplantar keratoderma | Multiple punctate hyperkeratotic papules on palms and soles; may form hyperkeratotic plaques in sites of friction or pressure. |
| Tinea pedis | Interdigital macerated and erythematous plaques, fine scaling on the plantar and lateral surfaces of the feet, or a vesicobullous eruption on the instep of the foot; potassium hydroxide preparation reveals fungal hyphae. |
| Tungiasis | Ectoparasitic infection caused by gravid female sand flea; nonmigratory papule or nodule with central black dot; often located on feet. |
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