Salivary gland histopathology in Sjögren's disease

Salivary gland histopathology.

(A) Normal minor labial salivary gland tissue. Note the striated duct in the center (arrow) and the surrounding mucus-secreting acini.

(B) A cross-section of a salivary gland lobule from a patient with Sjögren's disease. Note the multiple dense lymphocytic aggregates adjacent to normal-appearing mucus-secreting acini. This histopathologic pattern is designated "focal lymphocytic sialadenitis."

(C) Parotid gland parenchymal tissue from a patient with Sjögren's disease. There are dense lymphocytic aggregates surrounding excretory ducts. Lymphoid follicles are present in the infiltrates (arrow). This histologic pattern is designated "benign lymphoepithelial sialadenitis."