Relationship between the continuous Recurrence Score (RS) from Oncotype DX and five-year recurrence risk by stage and treatment in NSABP C-07 trial

Relationship between the continuous RS and 5-year recurrence risk by stage and treatment in NSABP C-07. Thick lines represent fluorouracil (FU)-treated patients, thin lines represent FU plus oxaliplatin-treated patients. A rug plot depicting the distribution of RS is included at the bottom of the continuous RS and 5-year recurrence risk figure, and an estimated normal distribution of scores is provided below. The proportional hazards assumption held (p = 0.20 for the test of nonzero slope of Schoenfeld residuals versus time). The relationship between continuous RS and the log hazard of recurrence was linear (p = 0.84 for the test of nonlinearity).