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تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Approach to antibiotic treatment in patients with persistent Helicobacter pylori infection

Approach to antibiotic treatment in patients with persistent Helicobacter pylori infection
  • Clarithromycin-based triple therapy consists of clarithromycin, amoxicillin/metronidazole, and a PPI.
  • Bismuth quadruple therapy consists of bismuth subsalicylate or bismuth subcitrate, metronidazole, tetracycline, and a PPI.
  • Levofloxacin triple therapy consists of levofloxacin, amoxicillin/metronidazole, and a PPI.
  • High-dose dual therapy consists of amoxicillin and a PPI.
  • Rifabutin triple therapy consists of rifabutin, amoxicillin, and a PPI.
  • Clarithromycin-based concomitant therapy consists of clarithromycin, amoxicillin, nitroimidazole (eg, metronidazole), and a PPI.
* Eradication of H. pylori after antibiotic treatment may be confirmed by a urea breath test, stool antigen test, or upper endoscopy-based testing. A positive result on one of these tests is indicative of a persistent H. pylori infection.
¶ If known levofloxacin sensitive strain or the population levofloxacin resistance rates are known to be less than 15%.
Δ Only in patients with no risk factors for macrolide resistance (no prior macrolide exposure and local clarithromycin resistance known to be <15%). This regimen should be avoided if local clarithromycin resistance is unknown.
Eradication of H. pylori infection can be confirmed with a urea breath test, stool antigen testing, or upper endoscopy-based testing. The choice of test depends on the need for an upper endoscopy (eg, follow-up of bleeding peptic ulcer) and local availability. H. pylori serology should not be used to confirm eradication of H. pylori. Refer to UpToDate topic on diagnostic tests for H. pylori.
Graphic 112679 Version 2.0

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