Salvage therapy for local, regionally recurrent, or second primary HNSCC

HNSCC: head and neck squamous cell carcinoma; RT: radiation therapy.
* Factors to consider in evaluating potential suitability for salvage therapy include the extent of local disease and the nature and extent of prior treatment, as well as the overall medical condition, including comorbidity.
¶ Refer to the discussion in the topic on treatment of metastatic and recurrent head and neck cancer.
Δ Factors to consider include the extent and location of recurrent disease, type of prior treatment, time to recurrence, and toxicity of prior treatment.
◊ Salvage reirradiation requires an adequate dose (>60 Gy) for control of the tumor, as well as the use of contemporary, highly conformal techniques to minimize toxicity. Stereotactic body RT may also be an option for appropriately selected cases.