Main MRI changes in CADASIL

(A) Lacunar infarcts shown on T1-weighted imaging are mainly located in the brainstem (pons), thalamus, and lentiform nuclei in a 61-year-old man with a history of stroke, gait difficulties, and executive dysfunction with memory deficits.
(B) Small deep infarcts are shown on fluid-attenuated inversion recovery images in association with diffuse and confluent white-matter hyperintensities involving the anterior part of the temporal lobes.
(C) Microbleeds are visible on T2 or gradient-echo images as small hypointense foci in the thalamus and brainstem.