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تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Lifestyle modification for diabetes prevention

Lifestyle modification for diabetes prevention
Trial n Age
(years)		 BMI
(kg/m2)		 Intervention Study duration
(years)		 Weight loss
(mean reduction, kg)		 Cumulative incidence diabetes*
Lifestyle modification versus control Lifestyle modification versus control
Finnish Diabetes Prevention Study[1] 522 55 31 Lifestyle modification, control 3.2 3.5 versus 0.8 11 versus 23%
Diabetes Prevention Program[2] 3234 51 34 Lifestyle modification, metformin, placebo 3 5.6 versus 0.1 14 versus 29%
China Da Qing Diabetes Prevention Study[3] 577 45 25.8 Diet, exercise, diet + exercise, control 6 2.6 (diet + exercise) versus 0.6 46 (diet + exercise) versus 67.7%
Zensharen Study for Prevention of Lifestyle Diseases[4] 641 49 27 Lifestyle modification (frequent intervention), control 3 2.5 versus 1.1 12.2 versus 16.6%
Trials comparing lifestyle modification with usual care in patients with impaired glucose tolerance or impaired fasting glucose. Lifestyle modifications are typically composed of exercise, diet, and behavioral modification. Age, BMI, and study duration presented as mean (except Zensharen; age reported as median).
BMI: body mass index.
* Diabetes diagnosed by fasting hyperglycemia or 2-hour plasma glucose tolerance test.
¶ Metformin arm, incidence of diabetes 22%.
References:
  1. Tuomilehto J, Lindström J, Eriksson JG, et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001; 344:1343.
  2. Knowler WC, Barrett-Connor E, Fowler SE, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346:393.
  3. Pan XR, Li GW, Hu YH, et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care 1997; 20:537.
  4. Saito T, Watanabe M, Nishida J, et al. Lifestyle modification and prevention of type 2 diabetes in overweight Japanese with impaired fasting glucose levels: A randomized controlled trial. Arch Intern Med 2011; 171:1352.
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