The definitions of the T categories correspond to the stages accepted by the Fédération Internationale de Gynécologie et d'Obstétrique (FIGO). Both systems are included for comparison. | |||
Primary tumor (T) | |||
T category | FIGO stage | T criteria | |
TX | Primary tumor cannot be assessed | ||
T0 | No evidence of primary tumor | ||
T1 | I | Tumor confined to the corpus uteri, including endocervical glandular involvement | |
T1a | IA | Tumor limited to the endometrium or invading less than half the myometrium | |
T1b | IB | Tumor invading one half or more of the myometrium | |
T2 | II | Tumor invading the stromal connective tissue of the cervix but not extending beyond the uterus. Does NOT include endocervical glandular involvement. | |
T3 | III | Tumor involving serosa, adnexa, vagina, or parametrium | |
T3a | IIIA | Tumor involving the serosa and/or adnexa (direct extension or metastasis) | |
T3b | IIIB | Vaginal involvement (direct extension or metastasis) or parametrial involvement | |
T4 | IVA | Tumor invading the bladder mucosa and/or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4) | |
T suffix (m) if synchronous primary tumors are found in a single organ. | |||
Regional lymph nodes (N) | |||
N category | FIGO stage | N criteria | |
NX | Regional lymph nodes cannot be assessed | ||
N0 | No regional lymph node metastasis | ||
N0(i+) | Isolated tumor cells in regional lymph node(s) no greater than 0.2 mm | ||
N1 | IIIC1 | Regional lymph node metastasis to pelvic lymph nodes | |
N1mi | IIIC1 | Regional lymph node metastasis (greater than 0.2 mm but not greater than 2.0 mm in diameter) to pelvic lymph nodes | |
N1a | IIIC1 | Regional lymph node metastasis (greater than 2.0 mm in diameter) to pelvic lymph nodes | |
N2 | IIIC2 | Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes | |
N2mi | IIIC2 | Regional lymph node metastasis (greater than 0.2 mm but not greater than 2.0 mm in diameter) to para-aortic lymph nodes, with or without positive pelvic lymph nodes | |
N2a | IIIC2 | Regional lymph node metastasis (greater than 2.0 mm in diameter) to para-aortic lymph nodes, with or without positive pelvic lymph nodes | |
Suffix (sn) is added to the N category when regional lymph node metastasis is identified by sentinel lymph node biopsy only. Suffix (f) is added to the N category when metastasis is identified by fine needle aspiration (FNA) or core needle biopsy only. | |||
Distant metastasis (M) | |||
M category | FIGO stage | M criteria | |
cM0 | No distant metastasis | ||
cM1 | IVB | Distant metastasis (includes to inguinal lymph nodes, intraperitoneal disease, lung, liver, or bone). (It excludes metastasis to pelvic or para-aortic lymph nodes, vagina, uterine serosa, or adnexa.) | |
pM1 | IVB | Distant metastasis (includes to inguinal lymph nodes, intraperitoneal disease, liver, or bone) microscopically confirmed. (It excludes metastasis to pelvic or para-aortic lymph nodes, vagina, uterine serosa, or adnexa.) | |
Prognostic stage groups | |||
When T is... | And N is... | And M is... | Then the stage group is... |
T1 | N0 | M0 | I |
T1a | N0 | M0 | IA |
T1b | N0 | M0 | IB |
T2 | N0 | M0 | II |
T3 | N0 | M0 | III |
T3a | N0 | M0 | IIIA |
T3b | N0 | M0 | IIIB |
T1-T3 | N1/N1mi/N1a | M0 | IIIC1 |
T1-T3 | N2/N2mi/N2a | M0 | IIIC2 |
T4 | Any N | M0 | IVA |
Any T | Any N | M1 | IVB |
Histologic grade (G) | |||
G | G definition | ||
GX | Grade cannot be assessed | ||
G1 | Well differentiated | ||
G2 | Moderately differentiated | ||
G3 | Poorly differentiated | ||
Histopathology: Degree of differentiation | |||
Cases of carcinoma of the corpus uteri should be grouped according to the degree of differentiation of the endometrioid adenocarcinoma: | |||
G | G definition | ||
G1 | 5% or less of a nonsquamous or nonmorular solid growth pattern | ||
G2 | 6-50% of a nonsquamous or nonmorular solid growth pattern | ||
G3 | More than 50% of a nonsquamous or nonmorular solid growth pattern. Papillary serous, clear cell, and carcinosarcoma are considered high grade. | ||
NOTES on pathologic grading:
| |||
Lymphovascular invasion (LVI) | |||
Component of LVI coding | Description | ||
0 | LVI not present (absent)/not identified | ||
1 | LVI present/identified, NOS | ||
2 | Lymphatic and small vessel invasion only (L) | ||
3 | Venous (large vessel) invasion only (V) | ||
4 | BOTH lymphatic and small vessel AND venous (large vessel) invasion | ||
9 | Presence of LVI unknown/indeterminate |
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