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Corpus uteri: Carcinoma and carcinosarcoma TNM staging AJCC UICC 8th edition

Corpus uteri: Carcinoma and carcinosarcoma TNM staging AJCC UICC 8th edition
The definitions of the T categories correspond to the stages accepted by the Fédération Internationale de Gynécologie et d'Obstétrique (FIGO). Both systems are included for comparison.
Primary tumor (T)
T category FIGO stage T criteria
TX   Primary tumor cannot be assessed
T0   No evidence of primary tumor
T1 I Tumor confined to the corpus uteri, including endocervical glandular involvement
T1a IA Tumor limited to the endometrium or invading less than half the myometrium
T1b IB Tumor invading one half or more of the myometrium
T2 II Tumor invading the stromal connective tissue of the cervix but not extending beyond the uterus. Does NOT include endocervical glandular involvement.
T3 III Tumor involving serosa, adnexa, vagina, or parametrium
T3a IIIA Tumor involving the serosa and/or adnexa (direct extension or metastasis)
T3b IIIB Vaginal involvement (direct extension or metastasis) or parametrial involvement
T4 IVA Tumor invading the bladder mucosa and/or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4)
T suffix (m) if synchronous primary tumors are found in a single organ.
Regional lymph nodes (N)
N category FIGO stage N criteria
NX   Regional lymph nodes cannot be assessed
N0   No regional lymph node metastasis
N0(i+)   Isolated tumor cells in regional lymph node(s) no greater than 0.2 mm
N1 IIIC1 Regional lymph node metastasis to pelvic lymph nodes
N1mi IIIC1 Regional lymph node metastasis (greater than 0.2 mm but not greater than 2.0 mm in diameter) to pelvic lymph nodes
N1a IIIC1 Regional lymph node metastasis (greater than 2.0 mm in diameter) to pelvic lymph nodes
N2 IIIC2 Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes
N2mi IIIC2 Regional lymph node metastasis (greater than 0.2 mm but not greater than 2.0 mm in diameter) to para-aortic lymph nodes, with or without positive pelvic lymph nodes
N2a IIIC2 Regional lymph node metastasis (greater than 2.0 mm in diameter) to para-aortic lymph nodes, with or without positive pelvic lymph nodes

Suffix (sn) is added to the N category when regional lymph node metastasis is identified by sentinel lymph node biopsy only.

Suffix (f) is added to the N category when metastasis is identified by fine needle aspiration (FNA) or core needle biopsy only.
Distant metastasis (M)
M category FIGO stage M criteria
cM0   No distant metastasis
cM1 IVB Distant metastasis (includes to inguinal lymph nodes, intraperitoneal disease, lung, liver, or bone).
(It excludes metastasis to pelvic or para-aortic lymph nodes, vagina, uterine serosa, or adnexa.)
pM1 IVB Distant metastasis (includes to inguinal lymph nodes, intraperitoneal disease, liver, or bone) microscopically confirmed.
(It excludes metastasis to pelvic or para-aortic lymph nodes, vagina, uterine serosa, or adnexa.)
Prognostic stage groups
When T is... And N is... And M is... Then the stage group is...
T1 N0 M0 I
T1a N0 M0 IA
T1b N0 M0 IB
T2 N0 M0 II
T3 N0 M0 III
T3a N0 M0 IIIA
T3b N0 M0 IIIB
T1-T3 N1/N1mi/N1a M0 IIIC1
T1-T3 N2/N2mi/N2a M0 IIIC2
T4 Any N M0 IVA
Any T Any N M1 IVB
Histologic grade (G)
G G definition
GX Grade cannot be assessed
G1 Well differentiated
G2 Moderately differentiated
G3 Poorly differentiated
Histopathology: Degree of differentiation
Cases of carcinoma of the corpus uteri should be grouped according to the degree of differentiation of the endometrioid adenocarcinoma:
G G definition
G1 5% or less of a nonsquamous or nonmorular solid growth pattern
G2 6-50% of a nonsquamous or nonmorular solid growth pattern
G3 More than 50% of a nonsquamous or nonmorular solid growth pattern. Papillary serous, clear cell, and carcinosarcoma are considered high grade.
NOTES on pathologic grading:
  1. Notable nuclear atypia exceeding that which is routinely expected for the architectural grade increases the tumor grade by 1 (ie, 1 to 2 and 2 to 3).
  2. Serous, clear cell, and mixed mesodermal tumors are high risk and considered grade 3.
  3. Adenocarcinomas with benign squamous elements (squamous metaplasia) are graded according to the nuclear grade of the glandular component.
Lymphovascular invasion (LVI)
Component of LVI coding Description
0 LVI not present (absent)/not identified
1 LVI present/identified, NOS
2 Lymphatic and small vessel invasion only (L)
3 Venous (large vessel) invasion only (V)
4 BOTH lymphatic and small vessel AND venous (large vessel) invasion
9 Presence of LVI unknown/indeterminate
TNM: Tumor, Node, Metastasis; NOS: not otherwise specified.
Used with permission of the American College of Surgeons, Chicago, Illinois. The original source for this information is the AJCC Cancer Staging Manual, Eighth Edition (2017) published by Springer International Publishing.
Graphic 113543 Version 14.0

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