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General antimicrobial susceptibility patterns for the most common Nocardia species

General antimicrobial susceptibility patterns for the most common Nocardia species
  N. farcinica N. nova N. brasiliensis N. cyriacigeorgica N. abscessus N. otitidiscaviarum
Trimethoprim-sulfamethoxazole S S S S S S
Imipenem S S R S S R
Amikacin S S S S S S
Linezolid S S S S S S
Tobramycin R R S S S S
Amoxicillin-clavulanate S R S R S R
Ceftriaxone R S R S S R
Ciprofloxacin R R R R R R
Clarithromycin R S R R R R
Doxycycline R R R R S R
Minocycline R R R R S R
Erythromycin R S R R R R
Common antimicrobial susceptibility patterns for the most common Nocardia species are outlined in the table; species are labeled as susceptible if >80% of isolates tested were susceptible and as resistant if >80% of isolates tested were resistant. Such data may be of use when therapy is commenced before antimicrobial susceptibility results are available. The table summarizes data extracted from four studies.[1-3] The four studies included are not directly comparable because of differences in the number of isolates and species included, antibiotics tested, and the methods of susceptibility testing used. Moxifloxacin was included in only one study; in this report, 81% of 36 N. farcinica isolates were susceptible to moxifloxacin.[2]
S: susceptible; R: resistant.
References:
  1. Valdezate S, Garrido N, Carrasco G, et al. Epidemiology and susceptibility to antimicrobial agents of the main Nocardia species in Spain. J Antimicrob Chemother 2017; 72:754.
  2. McTaggart LR, Doucet J, Witkowska M, Richardson SE. Antimicrobial susceptibility among clinical Nocardia species identified by multilocus sequence analysis. Antimicrob Agents Chemother 2015; 59:269.
  3. Uhde KB, Pathak S, McCullum I Jr, et al. Antimicrobial-resistant nocardia isolates, United States, 1995-2004. Clin Infect Dis 2010; 51:1445.
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