Pharmacokinetic properties of aminosteroid nondepolarizing neuromuscular blocking agents in infants, children, and adults*

	Rocuronium				Vecuronium
	Infant	Child	Adult	Elderly	Infant	Child	Adult	Elderly
ED₉₅ (mg/kg)	0.3	0.4	0.3	0.3	0.05	0.08	0.05	0.05
V_D (L/kg)	0.2	0.17	0.3 to 0.7	0.2 to 0.6	0.35	0.20	0.4	0.3
t_½-Beta (minutes)	50 to 110	25 to 110	100 to 250	110 to 280	65	41.0	65 to 75	70 to 180
Onset time (minutes)	0.6	1.3	1.5 to 3	2 to 5	1.5	2.4	3 to 4	3 to 4
Dosing interval (minutes)	42 to 100	27	30 to 70	22 to 73	59	37	25 to 50	49 to 97

Onset times and dosing intervals are averages for a 2 × ED₉₅ dose. Infant: 0 to 1 year; Child: 1 to 18 years; Adult: 18 to 65 years; Elderly: >65 years.

ED₉₅: effective dose required to achieve 95% depression in evoked twitch response; V_D: volume of distribution; t_½-Beta: elimination half-life.
* The data are averages obtained from published literature and do not account for other influences such as volatile anesthetics, organ dysfunction, etc.

Adapted from: Brull SJ. Neuromuscular blocking agents. In: Clinical Anesthesia, 8th ed, Barash PG, Cullen BF, Stoelting RK, et al (Eds), Wolters Kluwer 2017. p.527.

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خرید پکیج

Pharmacokinetic properties of aminosteroid nondepolarizing neuromuscular blocking agents in infants, children, and adults*