Steroidogenesis in adrenal cortex affected by specific enzyme inhibitors*

Steroidogenesis in the adrenal cortex denoting the specific pathways inhibited by ketoconazole (KTZ), metyrapone (MTR), mitotane, etomidate, and newer steroidogenesis inhibitors.

17-alpha-OH: 17-alpha-hydroxylase; DHEAS: dehydroepiandrosterone sulfate; 3-beta-HSD: 3-beta-hydroxysteroid dehydrogenase; 21-OH: 21-hydroxylase; 11-beta-OH: 11-beta-hydroxylase; LCI699: osilodrostat; 18-OH: 18-hydroxylase.
* Refer to UpToDate table for nomenclature used for steroidogenic enzymes.
¶ Aldosterone synthase.

From: Daniel E, Newell-Price JD. Therapy of endocrine disease: Steroidogenesis enzyme inhibitors in Cushing's syndrome. Eur J Endocrinol 2015; 172:R263. Copyright © 2015 BioScientifica Ltd. All rights reserved.

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Steroidogenesis in adrenal cortex affected by specific enzyme inhibitors*