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Steroidogenesis in adrenal cortex affected by specific enzyme inhibitors*

Steroidogenesis in adrenal cortex affected by specific enzyme inhibitors*
Steroidogenesis in the adrenal cortex denoting the specific pathways inhibited by ketoconazole, metyrapone, mitotane, etomidate, and newer steroidogenesis inhibitors.

3-beta-HSD: 3-beta-hydroxysteroid dehydrogenase; 11-beta-OH: 11-beta-hydroxylase; 17-alpha-OH: 17-alpha-hydroxylase; 18-OH: 18-hydroxylase; 21-OH: 21-hydroxylase; DHEAS: dehydroepiandrosterone sulfate; LCI699: osilodrostat.

* Refer to UpToDate table for nomenclature used for steroidogenic enzymes.

¶ Aldosterone synthase.
From: Daniel E, Newell-Price JD. Therapy of endocrine disease: Steroidogenesis enzyme inhibitors in Cushing's syndrome. Eur J Endocrinol 2015; 172:R263. Copyright © 2015 BioScientifica Ltd. All rights reserved.
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