Version June 2024
| Study | Participants (n) | Short detection controls | Prolonged detection intervention | Findings |
| PREPARE | 1391 Nonrandomized Primary prevention | 12 of 16 (58%) beats 18 of 24 (42%) beats | 30 of 40 beats | Reduction in inappropriate shocks (SVT), avoidable shocks (VT), and "morbidity index" |
| RELEVANT | 324 Nonrandomized Primary prevention | 12 of 16 beats | 30 of 40 beats | Reduction in inappropriate shocks (SVT), avoidable shocks (VT), and HF hospitalizations |
| MADIT-RIT | 1500 Randomized Primary prevention | 2.5 seconds (170 to 199 bpm) 1 second (≥200 bpm) | 60 seconds (170 to 199 bpm) 12 seconds (200 to 249 bpm) 2.5 seconds (≥250 bpm) | Reduction in first inappropriate therapy, first appropriate therapy, appropriate ATP, and inappropriate ATP; improved survival |
| ADVANCE-III | 1902 Randomized Primary and secondary prevention | 18 of 24 beats | 30 of 40 beats | Reduction in overall therapies, inappropriate shocks, and all-cause hospitalizations |
| PROVIDE | 1670 Randomized Primary prevention | 12 beats | 25 beats (180 to 214 bpm) 18 beats (214 to 250 bpm) 12 beats (>250 bpm) | Reduction in all-cause shock rate; improved survival |
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