Version May 2024
There are no adverse reactions listed in the manufacturer's labeling.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution, Perfusion:
Plegisol: Calcium chloride dihydrate 17.6 mg, magnesium chloride hexahydrate 325.3 mg, potassium chloride 119.3 mg, and sodium chloride 643 mg per 100 mL (1000 mL) [latex free]
Generic: Calcium chloride dihydrate 17.6 mg, magnesium chloride hexahydrate 325.3 mg, potassium chloride 119.3 mg, and sodium chloride 643 mg per 100 mL (1000 mL)
Yes
Cardioplegic solution must be buffered with sodium bicarbonate 8.4% for pH adjustment prior to cardiac instillation. To achieve an approximate pH of 7.8, 10 mL of sodium bicarbonate 8.4% must be added aseptically and thoroughly mixed with each 1,000 mL of cardioplegic solution. Not for intravenous injection; for cardiac instillation only.
Cardiac arrest induction: When appropriately buffered, solution is used to induce cardiac arrest during open heart surgery, in combination with ischemia and hypothermia.
The Institute for Safe Medication Practices (ISMP) includes this medication among its list of drugs that have a heightened risk of causing significant patient harm when used in error.
None known.
There are no known significant interactions.
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