Symptomatic management of diabetic muscle infarction*

NSAID: nonsteroidal antiinflammatory drug; COX-2: cyclooxygenase-2.
* Refer to UpToDate topic on diabetic muscle infarction.
¶ Refer to UpToDate topics on management of adults with diabetes mellitus.
Δ Contraindications to NSAIDs may include renal disease, hypertension, heart failure, ischemic heart disease, anticoagulation therapy, and risk of peptic ulcer disease and gastrointestinal hemorrhage. Refer to UpToDate content on adverse effects of nonselective and COX-2 selective NSAIDs for further discussion of contraindications to the use of NSAIDs and of their adverse effects.
◊ In patients on both aspirin and an NSAID, refer to UpToDate topic on cardiovascular adverse effects of NSAIDs for a discussion of coadministration of aspirin and NSAIDs.
§ Refer to UpToDate topic on the treatment of chronic non-cancer pain for a discussion of management of nociceptive pain.