Starting dosing regimens for sirolimus in neonates and infants

Age group (months)	Dose (mg/m²/dose every 12 hours)
Age group (months)	Target range: 6 to 10 ng/mL (predose concentration or "trough")	Target range: 10 to 15 ng/mL (predose concentration or "trough")
0 to 1	0.28	0.4
1 to 2	0.34	0.5
2 to 3	0.4	0.6
3 to 4	0.46	0.7
4 to 6	0.58	0.9
6 to 9	0.7	1.1
9 to 12	0.82	1.3
12 to 24	1	1.4

Starting dosing regimens for sirolimus in neonates and infants. Simulations based on pharmacokinetic data in patient with vascular anomalies.

Data from: Mizuno T, Fukuda T, Emoto C, et al. Developmental pharmacokinetics of sirolimus: Implications for precision dosing in neonates and infants with complicated vascular anomalies. Pediatr Blood Cancer 2017.

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Starting dosing regimens for sirolimus in neonates and infants