Gallbladder Cancer Predictive Risk score to predict locoregional residual and distant disease based on pathology findings in patients with an incidentally found gallbladder cancer

T-Stage
Tis/T1a		0
T1b		1
T2		2
T3/T4		3
Grade
G1 (well differentiated)		1
G2 (moderately differentiated)		2
G3 (poorly differentiated)		3
LVI
Negative		1
Positive		2
PNI
Negative		1
Positive		2
Total:
Total risk	Locoregional residual (%)	Distant disease (%)
Low (3 to 4)	0	0
Intermediate (5 to 7)	24	3
High (8 to 10)	61	32

The values for each pathologic factor are added to obtain a total risk score, ranging from 3 to 10. Patients are categorized into either the low, intermediate, or high GBRS group based on their total risk score. Each progressive GBRS group is associated with an increased prevalence of locoregional residual disease (p = 0.01) and distant disease (p = 0.006) at the time of reoperation.

GBRS: Gallbladder Cancer Predictive Risk Score; LVI: lymphovascular invasion; PNI: perineural invasion.

Reprinted by permission from: Springer: Annals of Surgical Oncology. Ethun CG, Postlewait LM, Le N, et al. A novel pathology-based preoperative risk score to predict locoregional residual and distant disease and survival for incidental gallbladder cancer: A 10-institution study from the U.S. extrahepatic biliary malignancy consortium. Ann Surg Oncol 2017; 24:1343. Copyright © 2017. https://link.springer.com/journal/10434.

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خرید پکیج

Gallbladder Cancer Predictive Risk score to predict locoregional residual and distant disease based on pathology findings in patients with an incidentally found gallbladder cancer