International Metastatic Renal Cell Carcinoma Database Consortium criteria

Karnofsky performance status score <80

Time from original diagnosis to initiation of targeted therapy <1 year

Hemoglobin less than the lower limit of normal

Serum calcium greater than the upper limit of normal

Neutrophil count greater than the upper limit of normal

Platelet count greater than the upper limit of normal

Favorable risk: None of the above risk factors present.
Intermediate risk: 1 or 2 of the above risk factors present.
Poor risk: 3 or more risk factors present.

Adapted from: Heng DYC, Xie W, Regan MM, et al. External validation and comparison with other models of the International Metastatic Renal Cell Carcinoma Database Consortium prognostic model: A population-based study. Lancet Oncol 2013; 14:141.

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International Metastatic Renal Cell Carcinoma Database Consortium criteria