Version June 2024
| Medication | Initial dose | Recommended dose increase¶ | Therapeutic range | Max dose |
| Second-generation antipsychotics | ||||
| Aripiprazole[1] | ||||
| Preadolescent | 2 mg | 3 to 5 mg every three to five days (divided dose) | 5 to 20 mg | 20 mg |
| Adolescent | 2 mg | 3 to 5 mg every three to five days | 10 to 30 mg | 30 mg |
| Lurasidone[2] | ||||
| Preadolescent | 20 mg | 20 mg after one to three days | 20 to 40 mg | 40 mg |
| Adolescent | 40 mg | 40 mg after one to three days | 40 to 80 mg | 80 mg |
| Olanzapine[3] | ||||
| PreadolescentΔ | 2.5 mg | 2.5 mg every three to five days (divided dose) | 5 to 20 mg | 20 mg |
| AdolescentΔ | 5 mg | 5 mg every three to five days | 10 to 30 mg | 30 mg |
| Paliperidone[4] | ||||
| Preadolescent | 1.5 mg | 1.5 mg every five to seven days | 6 mg | 6 mg |
| Adolescent | 3 mg | 3 mg every five to seven days | 12 mg | 12 mg |
| Quetiapine[5] | ||||
| Preadolescent | 25 mg | 15 to 50 mg daily (divided twice daily or every eight hours) | 100 to 400 mg | 400 mg |
| Adolescent | 25 mg twice daily | 50 to 100 mg daily (divided twice daily or every eight hours) | 400 to 800 mg | 800 mg |
| Risperidone[6-8] | ||||
| Preadolescent | 0.25 mg | 0.25 to 0.5 mg increase every three to five days (divided dose) | 2 to 3 mg/day | 3 mg/day |
| Adolescent | 0.25 mg twice daily | 0.5 mg to 1 mg increase every three to five days (divided dose) | 3 to 6 mg/day | 6 mg/day |
| Clozapine[9,10] | ||||
| Preadolescent | 12.5 mg | 12.5 mg increase every three to five days (divided dose) | 150 to 900 mg | 900 mg |
| Adolescent | 25 mg | 25 mg increase every three to five days | 150 to 900 mg | 900 mg |
| First-generation antipsychotics | ||||
| Chlorpromazine | ||||
| Preadolescent | 50 mg | 50 mg every one to three days (divided twice daily or every eight hours) | 50 to 400 mg | 400 mg/day |
| Adolescent | 100 mg | 50 to 100 mg every one to three days (divided twice daily or every eight hours) | 100 to 400 mg | 600 mg/day |
| Haloperidol[11] | ||||
| Preadolescent | 1 mg | 0.5 mg to 1 mg every three to five days | 0.5 to 6 mg | 10 mg |
| Adolescent | 1 mg | 1 mg every three to five days | 3 to 24 mg | 24 mg |
| Perphenazine[12] | ||||
| Preadolescent | 2 to 4 mg twice daily | 4 to 8 mg every three to five days (divided twice daily or every eight hours) | 16 to 36 mg/day | 36 mg/day |
| Adolescent | 4 to 8 mg three times daily | 4 to 8 mg every two to three days (divided twice daily or every eight hours) | 24 to 64 mg/day | 64 mg/day |
* Weight, age, and exposure to previous antipsychotic medications should be taken into account when deciding upon dosing recommendations.
¶ If uncertain, we suggest starting with the lower dose and slower titration schedule.
Δ Preadolescent is generally defined as school age up until age 12 and adolescent is age 13 to 17.آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟
