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Calculator: PLASMIC score for estimating the likelihood of severe ADAMTS13 deficiency in adults with suspected TTP


Calculator: PLASMIC score for estimating the likelihood of severe ADAMTS13 deficiency in adults with suspected TTP

 

Platelet count <30,000/microL [<30 x 109/L]

One or more indicators of hemolysis:
      Reticulocyte count (percentage) >2.5%; or
      Haptoglobin undetectable; or
      Indirect bilirubin >2.0 mg/dL [>34 mcmol/L]

No active cancer in the preceding year

No history of solid organ or hematopoietic stem cell transplant

Mean corpuscular volume (MCV) <90 femtoliters

International normalized ratio (INR) <1.5

Creatinine <2.0 mg/dL [<177 mcmol/L]

 
Important: Inputs must be complete to perform calculation.

 
Total criteria point count:
 

 

Interpretation

 
PLASMIC score (points) Risk of severe ADAMTS13 deficiency
0 to 4 Low risk
5 Intermediate risk
6 to 7 High risk

 
Notes
  • The PLASMIC score is only intended for use in individuals suspected to have a thrombotic microangiopathy based on the finding of schistocytes on the blood smear.
  • Each criterion, if present, contributes one point to the total criteria point count. One point is added for one or more of the "Indicator of hemolysis" subcriteria, if present.
  • TTP: thrombotic thrombocytopenic purpura.
  • ADAMTS13: a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13.

 
Only digits 0 to 9 and a single decimal point (".") are acceptable as numeric inputs. Attempted input of other characters into a numeric field may lead to an incorrect result.

Information on this page may not appear correctly if printed.

Legal Notices and Disclaimer

All information contained in and produced by the EBMcalc system is provided for educational purposes only. This information should not be used for the diagnosis or treatment of any health problem or disease. THIS INFORMATION IS NOT INTENDED TO REPLACE CLINICAL JUDGMENT OR GUIDE INDIVIDUAL PATIENT CARE IN ANY MANNER. Click here for full notice and disclaimer.

EBMcalc is Copyright © 1998-2024 Foundation Internet Services, LLC

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