Type of drug reactions

Type of reaction	Common features
Non-allergic reaction	Adverse effects (eg, diarrhea, vomiting, yeast vaginitis) Family history of penicillin allergy but no personal history
Mild non-IgE-mediated reaction	Maculopapular rash (with or without itching) Medical record lists penicillin allergy but patient unaware of reaction
IgE-mediated reaction	Anaphylaxis Angioedema Wheezing Laryngeal edema Hypotension Hives/urticaria
Serious delayed reactions	Toxic epidermal necrolysis (TEN) Stevens-Johnson syndrome (SJS) Drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome (DRESS/DiHS) Other exfoliating dermatoses/erythroderma Serum sickness-like reactions Drug-induced cytopenias Drug-induced renal, hepatic, or other specific organ damage

IgE: immunoglobulin E.

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