NCI CTCAE v5.0 thrombotic thrombocytopenic purpura

Adverse event	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Thrombotic thrombocytopenic purpura			Laboratory findings with clinical consequences (eg, renal insufficiency, petechiae)	Life-threatening consequences (eg, CNS hemorrhage or thrombosis/embolism or renal failure)	Death

Thrombotic thrombocytopenic purpura is a disorder characterized by the presence of microangiopathic hemolytic anemia, thrombocytopenic purpura, fever, renal abnormalities, and neurologic abnormalities such as seizures, hemiplegia, and visual disturbances. It is an acute or subacute condition.

NCI CTCAE: National Cancer Institute Common Terminology Criteria for Adverse Events; CNS: central nervous system.

Reproduced from: Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0, November 2017, National Institutes of Health, National Cancer Institute. Available at: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf (Accessed March 27, 2018).

Graphic 117317 Version 1.0

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NCI CTCAE v5.0 thrombotic thrombocytopenic purpura