NCI CTCAE v5.0 constipation

Adverse event	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Constipation	Occasional or intermittent symptoms; occasional use of stool softeners, laxatives, dietary modification, or enema	Persistent symptoms with regular use of laxatives or enemas; limiting instrumental ADL*	Obstipation with manual evacuation indicated; limiting self-care ADL*	Life-threatening consequences; urgent intervention indicated	Death

Constipation is characterized by irregular and infrequent or difficult evacuation of the bowels.

NCI CTCAE: National Cancer Institute Common Terminology Criteria for Adverse Events; ADL: activities of daily living.
* Instrumental ADLs include preparing meals, shopping, using the telephone, managing money. Self-care ADLs include bathing, dressing/undressing, using the toilet, taking medications, and not bedridden.

Reproduced from: Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0, November 2017, National Institutes of Health, National Cancer Institute. Available at: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf (Accessed March 27, 2018).

Graphic 117320 Version 1.0

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NCI CTCAE v5.0 constipation